{"id":1703,"date":"2019-01-10T17:36:56","date_gmt":"2019-01-10T07:36:56","guid":{"rendered":"https:\/\/www.cognav.net\/?p=1703"},"modified":"2019-01-10T18:01:51","modified_gmt":"2019-01-10T08:01:51","slug":"the-nobel-prize-in-physiology-or-medicine-2014-was-awarded-to-john-okeefe-may-britt-moser-and-edvard-i-moser-for-their-discoveries-of-cells-that-constitute-a-positioning-system-in-the-brain","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=1703","title":{"rendered":"The Nobel Prize in Physiology or Medicine 2014 was awarded to John O’Keefe, May-Britt Moser and Edvard I. Moser “for their discoveries of cells that constitute a positioning system in the brain.”"},"content":{"rendered":"

A summary report of\u00a0the Nobel Prize in Physiology or Medicine 2014 on the www.nobelprize.org\u00a0<\/a><\/p>\n

The following content is excerpted from the reference -The Nobel Prize in Physiology or Medicine 2014. NobelPrize.org. Nobel Media AB 2019. Thu. 10 Jan 2019. <https:\/\/www.nobelprize.org\/prizes\/medicine\/2014\/summary\/><\/em><\/p>\n

How do we know where we are? How can we find the way from one place to another? And how can we store this information in such a way that we can immediately find the way the next time we trace the same path? This year\u2019s Nobel Laureates have discovered a positioning system, an \u201cinner GPS\u201d in the brain that makes it possible to orient ourselves in space, demonstrating a cellular basis for higher cognitive function.<\/p>\n

The Nobel Prize in Physiology or Medicine 2014 was divided, one half awarded to John O’Keefe<\/a>, the other half jointly to May-Britt Moser<\/a> and Edvard I. Moser<\/a> “for their discoveries of cells that constitute a positioning system in the brain.<\/strong><\/span>“<\/p>\n

The discoveries of John O\u2019Keefe<\/a>, May-Britt Moser<\/a> and Edvard Moser<\/a> have solved a problem that has occupied philosophers and scientists for centuries \u2013 how does the brain create a map of the space surrounding us and how can we navigate our way through a complex environment?<\/strong><\/span><\/p>\n

\"\"<\/a><\/p>\n

Pic source: https:\/\/www.nobelprize.org\/uploads\/2018\/06\/med_image_press_eng-6.pdf<\/a><\/p>\n

For further info, please read the report on the website\u00a0\u00a0https:\/\/www.nobelprize.org\/prizes\/medicine\/2014\/press-release\/\u00a0\u00a0<\/a><\/p>\n

Advanced information:<\/p>\n

Scientific Background: The Brain\u2019s Navigational Place and Grid Cell System<\/a><\/p>\n

John O’Keefe Nobel Lecture:\u00a0Spatial Cells in the Hippocampal Formation<\/a>\u00a0(Lecture slides<\/a>, Lecture\u00a0Note<\/a>\u00a0)<\/p>\n

May-Britt Moser Nobel Lecture:\u00a0Grid Cells, Place Cells and Memory<\/a> (Lecture slides<\/a>, Lecture\u00a0Note<\/a>)<\/p>\n

Edvard I. Moser Nobel Lecture:\u00a0Grid Cells and the Enthorinal Map of Space<\/a> (Lecture slides<\/a>, Lecture\u00a0Note<\/a>)<\/p>\n

\n Key references:
\n O\u2019Keefe, J., and Dostrovsky, J. (1971). The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely\u2010moving rat. Brain Research 34, 171-175.<\/p>\n

O\u2019Keefe, J. (1976). Place units in the hippocampus of the freely moving rat. Experimental Neurology 51, 78-109.<\/p>\n

Fyhn, M., Molden, S., Witter, M.P., Moser, E.I., Moser, M.B. (2004) Spatial representation in the entorhinal cortex. Science 305, 1258-1264.<\/p>\n

Hafting, T., Fyhn, M., Molden, S., Moser, M.B., and Moser, E.I. (2005). Microstructure of spatial map in the entorhinal cortex. Nature 436, 801-806.<\/p>\n

Sargolini, F., Fyhn, M., Hafting, T., McNaughton, B.L., Witter, M.P., Moser, M.B., and Moser, E.I. (2006). Conjunctive representation of position, direction, and velocity in the entorhinal cortex. Science 312, 758-762.<\/p>\n

 <\/p>\n

The Nobel Prize in Physiology or Medicine 2014. NobelPrize.org. Nobel Media AB 2019. Thu. 10 Jan 2019. <https:\/\/www.nobelprize.org\/prizes\/medicine\/2014\/summary\/><\/em><\/p>\n

A Chinese version report on\u00a0www.sciencenet.cn<\/a>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

A summary report of\u00a0the Nobel Prize in Physiology or Medicine 2014 on the www.nobelprize.org\u00a0 The following content is excerpted from the reference -The Nobel Prize in Physiology or Medicine 2014. NobelPrize.org. Nobel Media AB 2019. Thu. 10 Jan 2019. <https:\/\/www.nobelprize.org\/prizes\/medicine\/2014\/summary\/> How do we know where we are? How can we find the way from one […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[114,96,346],"tags":[406,103,404,405,104,403],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/1703"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1703"}],"version-history":[{"count":7,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/1703\/revisions"}],"predecessor-version":[{"id":1713,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/1703\/revisions\/1713"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1703"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1703"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1703"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}