{"id":1877,"date":"2019-05-07T20:48:41","date_gmt":"2019-05-07T10:48:41","guid":{"rendered":"https:\/\/www.cognav.net\/?p=1877"},"modified":"2019-05-07T20:50:17","modified_gmt":"2019-05-07T10:50:17","slug":"the-integration-of-goal-directed-signals-onto-spatial-maps-of-hippocampal-place-cells","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=1877","title":{"rendered":"The Integration of Goal-Directed Signals onto Spatial Maps of Hippocampal Place Cells"},"content":{"rendered":"

Aoki, Yuki, Hideyoshi Igata, Yuji Ikegaya, and Takuya Sasaki. “The Integration of Goal-Directed Signals onto Spatial Maps of Hippocampal Place Cells<\/strong><\/a>.” Cell Reports 27, no. 5 (2019): 1516-1527.<\/p>\n

Spatial firing of hippocampal\u00a0place cells<\/a>\u00a0varies depending\u00a0on the animal\u2019s\u00a0behavior<\/a>\u00a0relative to its\u00a0goals<\/a>. Here,\u00a0rats<\/a>\u00a0were trained to approach visually guided reward ports in a two-dimensional open\u00a0field<\/a>. Hippocampal place\u00a0cells<\/a>\u00a0encoded two independent pieces of information, spatial representation and goal-directed representation,<\/span> by amplifying\u00a0firing rates<\/a>\u00a0within their place fields specifically while the\u00a0animal<\/a>\u00a0was moving toward a specific goal location.<\/span><\/strong><\/p>\n

<\/a><\/p>\n

Fig source:\u00a0Aoki et al. 2019<\/p>\n

Irrespective\u00a0of running\u00a0speed<\/a>\u00a0and direction, substantial place-selective firing was observed that sustained a basal spatial map independent of goal-directed signals.\u00a0When animals were allowed to freely\u00a0forage<\/a>\u00a0in the field, in-field\u00a0firing rates<\/a>\u00a0similarly increased when the animals transiently ran toward remembered goal locations<\/strong><\/span>. Disruption of medial septal activity significantly decreased goal-directed firing while maintaining spatial representation patterns.<\/span><\/strong> The findings indicate that the integrated encoding of spatial and goal-directed signals<\/span><\/strong> by hippocampal circuits is crucial for flexible\u00a0spatial navigation<\/a>\u00a0to a goal location.<\/p>\n

For further info, please read the paper\u00a0Aoki et al. 2019.<\/p>\n

Aoki, Yuki, Hideyoshi Igata, Yuji Ikegaya, and Takuya Sasaki. “The Integration of Goal-Directed Signals onto Spatial Maps of Hippocampal Place Cells<\/strong><\/a>.” Cell Reports 27, no. 5 (2019): 1516-1527.<\/p>\n","protected":false},"excerpt":{"rendered":"

Aoki, Yuki, Hideyoshi Igata, Yuji Ikegaya, and Takuya Sasaki. “The Integration of Goal-Directed Signals onto Spatial Maps of Hippocampal Place Cells.” Cell Reports 27, no. 5 (2019): 1516-1527. Spatial firing of hippocampal\u00a0place cells\u00a0varies depending\u00a0on the animal\u2019s\u00a0behavior\u00a0relative to its\u00a0goals. Here,\u00a0rats\u00a0were trained to approach visually guided reward ports in a two-dimensional open\u00a0field. Hippocampal place\u00a0cells\u00a0encoded two independent pieces […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[460,97,473],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/1877"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1877"}],"version-history":[{"count":2,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/1877\/revisions"}],"predecessor-version":[{"id":1879,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/1877\/revisions\/1879"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1877"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1877"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}