{"id":1941,"date":"2019-06-24T18:04:24","date_gmt":"2019-06-24T08:04:24","guid":{"rendered":"https:\/\/www.cognav.net\/?p=1941"},"modified":"2019-06-24T18:04:24","modified_gmt":"2019-06-24T08:04:24","slug":"how-are-grid-cells-organized-in-the-mec","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=1941","title":{"rendered":"How are grid cells organized in the MEC?"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Gu, Yi, Sam Lewallen, Amina A. Kinkhabwala, Cristina Domnisoru, Kijung Yoon, Jeffrey L. Gauthier, Ila R. Fiete, and David W. Tank. &#8220;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S009286741831167X\"><strong>A map-like micro-organization of grid cells in the medial entorhinal cortex<\/strong><\/a>.&#8221; Cell 175, no. 3 (2018): 736-750.<\/span><\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\nHow the topography of neural circuits relates to their function remains unclear. Although topographic maps exist for sensory and motor variables, they are rarely observed for cognitive variables. <strong><span style=\"color: #ff0000;\">Using calcium imaging during virtual navigation, we investigated the relationship between the anatomical organization and functional properties of grid cells, which represent a cognitive code for location during navigation.<\/span> <span style=\"color: #ff0000;\">We found a substantial degree of grid cell micro-organization in mouse medial entorhinal cortex: grid cells and modules all clustered anatomically.<\/span> <span style=\"color: #ff0000;\">Within a module, the layout of grid cells was a noisy two-dimensional lattice in which the anatomical distribution of grid cells largely matched their spatial tuning phases. This micro-arrangement of phases demonstrates the existence of a topographical map encoding a cognitive variable in rodents.<\/span> <\/strong>It contributes to a foundation for evaluating circuit models of the grid cell network and is consistent with continuous attractor models as the mechanism of grid formation.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S009286741831167X-figs7.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S009286741831167X-figs7.jpg\" width=\"656\" height=\"594\" \/><\/a><\/p>\n<p><span class=\"label\">Figure\u00a0S7<\/span>.\u00a0Method for Calculating Missed-Field Patterns; Possible Mechanisms for Generating\u00a0<a title=\"Learn more about Grid Cell from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/grid-cell\">Grid Cells<\/a>\u00a0in\u00a0<a title=\"Learn more about Stellate Cell from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/stellate-cell\">Stellate Cells<\/a>\u00a0in Layer 2 of the MEC,\u00a0 (Source: <span style=\"color: #000000;\">Gu et al. 2018<\/span>)<\/p>\n<p>For further info, please read the paper\u00a0 <span style=\"color: #000000;\">Gu et al. 2018<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Gu, Yi, Sam Lewallen, Amina A. Kinkhabwala, Cristina Domnisoru, Kijung Yoon, Jeffrey L. Gauthier, Ila R. Fiete, and David W. Tank. &#8220;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S009286741831167X\"><strong>A map-like micro-organization of grid cells in the medial entorhinal cortex<\/strong><\/a>.&#8221; Cell 175, no. 3 (2018): 736-750.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gu, Yi, Sam Lewallen, Amina A. Kinkhabwala, Cristina Domnisoru, Kijung Yoon, Jeffrey L. Gauthier, Ila R. Fiete, and David W. Tank. &#8220;A map-like micro-organization of grid cells in the medial entorhinal cortex.&#8221; Cell 175, no. 3 (2018): 736-750. Summary How the topography of neural circuits relates to their function remains unclear. Although topographic maps exist [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[103,509],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/1941"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1941"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/1941\/revisions"}],"predecessor-version":[{"id":1942,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/1941\/revisions\/1942"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1941"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1941"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}