{"id":2011,"date":"2019-08-30T01:01:46","date_gmt":"2019-08-29T15:01:46","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2011"},"modified":"2019-08-30T01:04:18","modified_gmt":"2019-08-29T15:04:18","slug":"how-does-place-cell-network-pattern-develop-with-experience","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2011","title":{"rendered":"How does place cell network pattern develop with experience?"},"content":{"rendered":"<p style=\"text-align: left;\"><span class=\"highwire-citation-author first has-tooltip hasTooltip\" data-delta=\"0\" data-hasqtip=\"1\" aria-describedby=\"qtip-1\"><span class=\"nlm-given-names\">Soyoun<\/span>\u00a0<span class=\"nlm-surname\">Kim<\/span><\/span>,\u00a0<span class=\"highwire-citation-author has-tooltip hasTooltip\" data-delta=\"1\" data-hasqtip=\"2\" aria-describedby=\"qtip-2\"><span class=\"nlm-given-names\">Dajung<\/span>\u00a0<span class=\"nlm-surname\">Jung<\/span><\/span>,\u00a0<span class=\"highwire-citation-author has-tooltip hasTooltip\" data-delta=\"2\" data-hasqtip=\"0\" aria-describedby=\"qtip-0\"><span class=\"nlm-given-names\">Sebastien<\/span>\u00a0<span class=\"nlm-surname\">Royer.\u00a0<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/748640v1?ct=\"><strong>Place cell map genesis via competitive learning and conjunctive coding in the dentate gyrus<\/strong><\/a>.\u00a0<span class=\"highwire-cite-metadata-journal highwire-cite-metadata\">bioRxiv\u00a0<\/span><span class=\"highwire-cite-metadata-pages highwire-cite-metadata\">748640;\u00a0\u00a0<\/span><span class=\"highwire-cite-metadata-doi highwire-cite-metadata\"><span class=\"doi_label\">doi:<\/span>\u00a0https:\/\/doi.org\/10.1101\/748640<\/span><br \/>\n<\/span><\/span><\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Place cells exhibit spatially selective firing fields and collectively map the continuum of positions in environments; how such network pattern develops with experience remains unclear.<\/span><\/strong> Here, we recorded putative granule (GC) and mossy (MC) cells from the dentate gyrus (DG) over 27 days as mice repetitively ran through a sequence of objects fixed onto a treadmill belt. We observed a progressive transformation of GC spatial representations, from a sparse encoding of object locations and periodic spatial intervals to increasingly more single, evenly dispersed place fields, while MCs showed little transformation and preferentially encoded object locations.<span style=\"color: #ff0000;\"><strong> A competitive learning model of the DG reproduced GC transformations via the progressive integration of landmark-vector cells and grid cell inputs and required MC-mediated feed forward inhibition to evenly distribute GC representations, suggesting that GCs progressively encode conjunctions of objects and spatial information via competitive learning, while MCs help homogenize GC spatial representations<\/strong><\/span>.&#8221;<\/p>\n<p style=\"text-align: left;\"><span class=\"highwire-citation-author first has-tooltip hasTooltip\" data-delta=\"0\" data-hasqtip=\"1\" aria-describedby=\"qtip-1\"><span class=\"nlm-given-names\">Soyoun<\/span>\u00a0<span class=\"nlm-surname\">Kim<\/span><\/span>,\u00a0<span class=\"highwire-citation-author has-tooltip hasTooltip\" data-delta=\"1\" data-hasqtip=\"2\" aria-describedby=\"qtip-2\"><span class=\"nlm-given-names\">Dajung<\/span>\u00a0<span class=\"nlm-surname\">Jung<\/span><\/span>,\u00a0<span class=\"highwire-citation-author has-tooltip hasTooltip\" data-delta=\"2\" data-hasqtip=\"0\" aria-describedby=\"qtip-0\"><span class=\"nlm-given-names\">Sebastien<\/span>\u00a0<span class=\"nlm-surname\">Royer.\u00a0<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/748640v1?ct=\"><strong>Place cell map genesis via competitive learning and conjunctive coding in the dentate gyrus<\/strong><\/a>. <span class=\"highwire-cite-metadata-journal highwire-cite-metadata\">bioRxiv\u00a0<\/span><span class=\"highwire-cite-metadata-pages highwire-cite-metadata\">748640;\u00a0\u00a0<\/span><span class=\"highwire-cite-metadata-doi highwire-cite-metadata\"><span class=\"doi_label\">doi:<\/span>\u00a0https:\/\/doi.org\/10.1101\/748640<\/span><br \/>\n<\/span><\/span><\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Soyoun\u00a0Kim,\u00a0Dajung\u00a0Jung,\u00a0Sebastien\u00a0Royer.\u00a0Place cell map genesis via competitive learning and conjunctive coding in the dentate gyrus.\u00a0bioRxiv\u00a0748640;\u00a0\u00a0doi:\u00a0https:\/\/doi.org\/10.1101\/748640 Abstract &#8220;Place cells exhibit spatially selective firing fields and collectively map the continuum of positions in environments; how such network pattern develops with experience remains unclear. Here, we recorded putative granule (GC) and mossy (MC) cells from the dentate gyrus (DG) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,419,519],"tags":[541,540,308,97],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2011"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2011"}],"version-history":[{"count":4,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2011\/revisions"}],"predecessor-version":[{"id":2015,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2011\/revisions\/2015"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2011"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2011"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}