{"id":2049,"date":"2019-11-06T13:24:10","date_gmt":"2019-11-06T03:24:10","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2049"},"modified":"2019-11-06T13:24:59","modified_gmt":"2019-11-06T03:24:59","slug":"how-spatial-information-is-communicated-by-place-cells-to-downstream-areas-in-a-finer-theta-timescale","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2049","title":{"rendered":"How spatial information is communicated by place cells to downstream areas in a finer theta-timescale?"},"content":{"rendered":"<p style=\"text-align: justify;\">Monsalve\u2010Mercado, MM, Roudi, Y. <a href=\"https:\/\/onlinelibrary.wiley.com\/action\/showCitFormats?doi=10.1002%2Fhipo.23173\"><strong>Hippocampal spike\u2010time correlations and place field overlaps during open field foraging<\/strong><\/a>. Hippocampus. 2019; 1\u2013 13. https:\/\/doi.org\/10.1002\/hipo.23173<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<span style=\"color: #ff0000;\"><strong>Phase precessing place cells encode spatial information on fine timescales via the timing of their spikes<\/strong><\/span>. This phase code has been extensively studied on linear tracks and for short runs in the open field. However,<strong><span style=\"color: #ff0000;\"> less is known about the phase code on unconstrained trajectories lasting tens of minutes, typical of open field foraging.<\/span><\/strong> In previous work (Monsalve\u2010Mercado and Leibold, Physical Review Letters, 119, 38101 (2017)), an analytic expression was derived for the spike\u2010time cross\u2010correlation between phase precessing place cells during natural foraging in the open field. This expression makes two predictions on how this phase code differs from the linear track case: cross\u2010correlations are symmetric with respect to time, and they represent the distance between pairs of place fields in that the theta\u2010filtered cross\u2010correlations around zero time lag are positive for cells with nearby fields while they are negative for those with fields further apart. Here we analyze several available open field recordings and show that these predictions hold for pairs of CA1 place cells. We also show that the relationship remains during remapping in CA1, and it is also present in place cells in area CA3. For CA1 place cells of Fmr1\u2010null mice, which exhibit normal place fields but somewhat weaker temporal coordination with respect to theta compared to wild type, the cross\u2010correlations still remain symmetric but the relationship to place field overlap is largely lost. <span style=\"color: #ff0000;\"><strong>The relationship discussed here describes how spatial information is communicated by place cells to downstream areas in a finer theta\u2010timescale, relevant for learning and memory formation in behavioral tasks lasting tens of minutes in the open field<\/strong><\/span>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Monsalve\u2010Mercado, MM, Roudi, Y. <a href=\"https:\/\/onlinelibrary.wiley.com\/action\/showCitFormats?doi=10.1002%2Fhipo.23173\"><strong>Hippocampal spike\u2010time correlations and place field overlaps during open field foraging<\/strong><\/a>. Hippocampus. 2019; 1\u2013 13. https:\/\/doi.org\/10.1002\/hipo.23173<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Monsalve\u2010Mercado, MM, Roudi, Y. Hippocampal spike\u2010time correlations and place field overlaps during open field foraging. Hippocampus. 2019; 1\u2013 13. https:\/\/doi.org\/10.1002\/hipo.23173 Abstract &#8220;Phase precessing place cells encode spatial information on fine timescales via the timing of their spikes. This phase code has been extensively studied on linear tracks and for short runs in the open field. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346,419,519],"tags":[258,555,554],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2049"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2049"}],"version-history":[{"count":2,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2049\/revisions"}],"predecessor-version":[{"id":2051,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2049\/revisions\/2051"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2049"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2049"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2049"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}