{"id":2052,"date":"2019-11-06T13:29:47","date_gmt":"2019-11-06T03:29:47","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2052"},"modified":"2019-11-06T13:29:47","modified_gmt":"2019-11-06T03:29:47","slug":"how-the-hippocampal-spatial-circuit-represents-latent-information-independent-of-sensory-inputs-and-future-goals","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2052","title":{"rendered":"How the hippocampal spatial circuit represents latent information independent of sensory inputs and future goals?"},"content":{"rendered":"<p style=\"text-align: justify;\">Alexandra T. Keinath, Andres Nieto-posadas, Jennifer C. Robinson, Mark P. Brandon. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/824102v1\"><strong>DG-CA3 circuitry mediates hippocampal representations of latent information.<\/strong><\/a>bioRxiv 824102; doi: https:\/\/doi.org\/10.1101\/824102<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;Survival in complex environments necessitates a flexible navigation system that incorporates memory of recent behavior and associations. Yet, <span style=\"color: #ff0000;\"><strong>how the hippocampal spatial circuit represents latent information independent of sensory inputs and future goals has not been determined.<\/strong><\/span> To address this, we imaged the activity of large ensembles in subregion CA1 via wide-field fluorescent microscopy during a novel behavioral paradigm. <strong><span style=\"color: #ff0000;\">Our results demonstrated that latent information is represented through reliable firing rate changes during unconstrained navigation<\/span><\/strong>. We then hypothesized that the representation of latent information in CA1 is mediated by pattern separation\/completion processes instantiated upstream within the dentate gyrus (DG) and CA3 subregions. Indeed, CA3 ensemble recordings revealed an analogous code for latent information. Moreover, selective chemogenetic inactivation of DG-CA3 circuitry completely and reversibly abolished the CA1 representation of latent information. <span style=\"color: #ff0000;\"><strong>These results reveal a causal and specific role of DG-CA3 circuitry in the maintenance of latent information within the hippocampus<\/strong><\/span>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Alexandra T. Keinath, Andres Nieto-posadas, Jennifer C. Robinson, Mark P. Brandon. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/824102v1\"><strong>DG-CA3 circuitry mediates hippocampal representations of latent information.<\/strong><\/a>bioRxiv 824102; doi: https:\/\/doi.org\/10.1101\/824102<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alexandra T. Keinath, Andres Nieto-posadas, Jennifer C. Robinson, Mark P. Brandon. DG-CA3 circuitry mediates hippocampal representations of latent information.bioRxiv 824102; doi: https:\/\/doi.org\/10.1101\/824102 Abstract &#8220;Survival in complex environments necessitates a flexible navigation system that incorporates memory of recent behavior and associations. Yet, how the hippocampal spatial circuit represents latent information independent of sensory inputs and future [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346,419,519],"tags":[558,556,557,104],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2052"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2052"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2052\/revisions"}],"predecessor-version":[{"id":2053,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2052\/revisions\/2053"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2052"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2052"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}