{"id":2054,"date":"2019-11-06T13:36:10","date_gmt":"2019-11-06T03:36:10","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2054"},"modified":"2019-11-06T13:36:10","modified_gmt":"2019-11-06T03:36:10","slug":"how-the-brain-represents-landmarks","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2054","title":{"rendered":"How the brain represents landmarks?"},"content":{"rendered":"<p style=\"text-align: justify;\">Lukas F. Fischer, Raul Mojica Soto-Albors, Friederike Buck, Mark T. Harnett. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/811430v1\"><strong>Representation of Visual Landmarks in Retrosplenial Cortex<\/strong><\/a>. bioRxiv 811430; doi: https:\/\/doi.org\/10.1101\/811430<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<span style=\"color: #ff0000;\"><strong>The process by which visual information is incorporated into the brain\u2019s spatial framework to represent landmarks is poorly understood<\/strong><\/span>. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. Presenting the same environment but decoupled from mouse behavior degraded encoding fidelity. <strong><span style=\"color: #ff0000;\">Analyzing visual and motor responses showed that landmark codes were the result of supralinear integration<\/span><\/strong>. Surprisingly, V1 axons recorded in RSC showed similar receptive fields. However, they were less modulated by task engagement, indicating that landmark representations in RSC are the result of local computations. <span style=\"color: #ff0000;\"><strong>Our data provide cellular- and network-level insight into how RSC represents landmarks<\/strong><\/span>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Lukas F. Fischer, Raul Mojica Soto-Albors, Friederike Buck, Mark T. Harnett. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/811430v1\"><strong>Representation of Visual Landmarks in Retrosplenial Cortex<\/strong><\/a>. bioRxiv 811430; doi: https:\/\/doi.org\/10.1101\/811430<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lukas F. Fischer, Raul Mojica Soto-Albors, Friederike Buck, Mark T. Harnett. Representation of Visual Landmarks in Retrosplenial Cortex. bioRxiv 811430; doi: https:\/\/doi.org\/10.1101\/811430 Abstract &#8220;The process by which visual information is incorporated into the brain\u2019s spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346,419],"tags":[556,243,560,559],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2054"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2054"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2054\/revisions"}],"predecessor-version":[{"id":2055,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2054\/revisions\/2055"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}