{"id":2082,"date":"2019-11-15T12:03:10","date_gmt":"2019-11-15T02:03:10","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2082"},"modified":"2019-11-15T12:03:10","modified_gmt":"2019-11-15T02:03:10","slug":"how-the-brain-represents-sequential-relationships-among-discrete-nonspatial-events","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2082","title":{"rendered":"How the brain represents sequential relationships among discrete nonspatial events?"},"content":{"rendered":"<p style=\"text-align: justify;\">Babak Shahbaba, Lingge LI, Forest Agostinelli, Mansi Saraf, Gabriel A Elias, Pierre F Baldi, Norbert J Fortin.\u00a0<br \/>\n<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/840199v1\"><strong>Hippocampal ensembles represent sequential relationships among discrete nonspatial events<\/strong><\/a>.\u00a0<br \/>\nbioRxiv 840199; doi: https:\/\/doi.org\/10.1101\/840199<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">The hippocampus is critical to the temporal organization of our experiences, including the ability to remember past event sequences and predict future ones<\/span><\/strong>. Although this fundamental capacity is conserved across modalities and species, its <strong><span style=\"color: #ff0000;\">underlying neuronal mechanisms remain poorly understood<\/span><\/strong>. Here we recorded hippocampal ensemble activity as rats remembered a sequence of nonspatial events (5 odor presentations unfolding over several seconds), using a task with established parallels in humans. Using novel statistical methods and deep learning techniques, we then identified new forms of sequential organization in hippocampal activity linked with task performance. <strong><span style=\"color: #ff0000;\">We discovered that sequential firing fields (&#8220;time cells&#8221;) provided temporal information within and across events in the sequence, and that distinct types of task-critical information (stimulus identity, temporal order, and trial outcome) were also sequentially differentiated within event presentations<\/span><\/strong>. Finally, as previously only observed with spatial information, we report that<strong><span style=\"color: #ff0000;\"> the representations of past, present and future events were sequentially activated within individual event presentations, and that these sequential representations could be compressed within an individual theta cycle<\/span><\/strong>. These findings strongly suggest that <strong><span style=\"color: #ff0000;\">a fundamental function of the hippocampal network is to encode and preserve the sequential order of experiences, and use these representations to generate predictions to inform decision-making<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Babak Shahbaba, Lingge LI, Forest Agostinelli, Mansi Saraf, Gabriel A Elias, Pierre F Baldi, Norbert J Fortin.\u00a0<br \/>\n<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/840199v1\"><strong>Hippocampal ensembles represent sequential relationships among discrete nonspatial events<\/strong><\/a>.\u00a0<br \/>\nbioRxiv 840199; doi: https:\/\/doi.org\/10.1101\/840199<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Babak Shahbaba, Lingge LI, Forest Agostinelli, Mansi Saraf, Gabriel A Elias, Pierre F Baldi, Norbert J Fortin.\u00a0 Hippocampal ensembles represent sequential relationships among discrete nonspatial events.\u00a0 bioRxiv 840199; doi: https:\/\/doi.org\/10.1101\/840199 Abstract &#8220;The hippocampus is critical to the temporal organization of our experiences, including the ability to remember past event sequences and predict future ones. Although [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,419,519],"tags":[582,258,581,583],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2082"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2082"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2082\/revisions"}],"predecessor-version":[{"id":2083,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2082\/revisions\/2083"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}