{"id":2142,"date":"2019-12-21T14:47:20","date_gmt":"2019-12-21T04:47:20","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2142"},"modified":"2019-12-21T14:47:20","modified_gmt":"2019-12-21T04:47:20","slug":"how-specific-populations-of-cells-within-the-lec-contribute-to-the-integration-of-episodic-memory-components","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2142","title":{"rendered":"How specific populations of cells within the LEC contribute to the integration of episodic memory components?"},"content":{"rendered":"<p style=\"text-align: justify;\">Vandrey, Brianna, Derek LF Garden, Veronika Ambrozova, Christina McClure, Matthew F. Nolan, and James A. Ainge. &#8220;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0960982219314666\"><strong>Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory.<\/strong><\/a>&#8221; Current Biology (2019).<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Episodic memory requires different types of information to be bound together to generate representations of experiences<\/span><\/strong>. The lateral entorhinal cortex (LEC) and hippocampus are required for episodic-like memory in rodents [1, 2]. <strong><span style=\"color: #ff0000;\">The LEC is critical for integrating spatial and contextual information about objects<\/span><\/strong> [2, 3, 4, 5, 6]. Further, <strong><span style=\"color: #ff0000;\">LEC neurons encode objects in the environment and the locations where objects were previously experienced and generate representations of time during the encoding and retrieval of episodes<\/span><\/strong> [7, 8, 9, 10, 11, 12]. However, <strong><span style=\"color: #ff0000;\">it remains unclear how specific populations of cells within the LEC contribute to the integration of episodic memory components<\/span><\/strong>. Layer 2 (L2) of LEC manifests early pathology in Alzheimer\u2019s disease (AD) and related animal models [13, 14, 15, 16]. Projections to the hippocampus from L2 of LEC arise from fan cells in a superficial sub-layer (L2a) that are immunoreactive for reelin and project to the dentate gyrus [17, 18]. Here, <strong><span style=\"color: #ff0000;\">we establish an approach for selectively targeting fan cells using Sim1:Cre mice<\/span><\/strong>. Whereas complete lesions of the LEC were previously found to abolish associative recognition memory [2, 3], we report that, after selective suppression of synaptic output from fan cells, mice can discriminate novel object-context configurations but are impaired in recognition of novel object-place-context associations. <strong><span style=\"color: #ff0000;\">Our results suggest that memory functions are segregated between distinct LEC networks<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Vandrey, Brianna, Derek LF Garden, Veronika Ambrozova, Christina McClure, Matthew F. Nolan, and James A. Ainge. &#8220;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0960982219314666\"><strong>Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory.<\/strong><\/a>&#8221; Current Biology (2019).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vandrey, Brianna, Derek LF Garden, Veronika Ambrozova, Christina McClure, Matthew F. Nolan, and James A. Ainge. &#8220;Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory.&#8221; Current Biology (2019). Summary &#8220;Episodic memory requires different types of information to be bound together to generate representations of experiences. The lateral entorhinal cortex [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,636,519],"tags":[639,169,638,637,148,641,640],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2142"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2142"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2142\/revisions"}],"predecessor-version":[{"id":2143,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2142\/revisions\/2143"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}