{"id":2166,"date":"2020-01-06T12:18:58","date_gmt":"2020-01-06T02:18:58","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2166"},"modified":"2020-01-06T12:18:58","modified_gmt":"2020-01-06T02:18:58","slug":"how-the-human-brain-codes-for-current-remote-spatial-target-locations","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2166","title":{"rendered":"How the human brain codes for current remote spatial target locations?"},"content":{"rendered":"<p style=\"text-align: justify;\">Tsitsiklis, Melina, Jonathan Miller, Salman E. Qasim, Cory S. Inman, Robert E. Gross, Jon R. Willie, Elliot H. Smith et al. &#8220;<a href=\"https:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(19)31518-0\"><strong>Single-neuron representations of spatial memory targets in humans<\/strong><\/a>.&#8221;\u00a0<i>BioRxiv<\/i>\u00a0(2019): 523753.<\/p>\n<p style=\"text-align: justify;\"><strong>Highlights<\/strong><br \/>\n\u2022 Epilepsy patients performed a spatial navigation task during single-neuron recordings<br \/>\n\u2022 Neuronal firing in the medial temporal lobe represents spatial target locations<br \/>\n\u2022 Single-neuron activity does not represent the subject\u2019s own location in this task<br \/>\n\u2022 Neuronal activity also varied with heading direction and order of navigation periods<br \/>\n<strong>Summary<\/strong><br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">The hippocampus and surrounding medial-temporal-lobe (MTL) structures are critical for both memory and spatial navigation, but we do not fully understand the neuronal representations used to support these behaviors.<\/span><\/strong> Much research has examined how the MTL neurally represents spatial information, such as with \u201cplace cells\u201d that represent an animal\u2019s current location or \u201chead-direction cells\u201d that code for an animal\u2019s current heading. <span style=\"color: #ff0000;\"><strong>In addition to behaviors that require an animal to attend to the current spatial location, navigating to remote destinations is a common part of daily life<\/strong><\/span>. To examine the neural basis of these behaviors, we recorded single-neuron activity from neurosurgical patients playing Treasure Hunt, a virtual-reality spatial-memory task. By analyzing how the activity of these neurons related to behavior in Treasure Hunt, <strong><span style=\"color: #ff0000;\">we found that the firing rates of many MTL neurons during navigation significantly changed depending on the position of the current spatial target<\/span><\/strong>. In addition, we observed neurons whose firing rates during navigation were tuned to specific heading directions in the environment, and others whose activity changed depending on the timing within the trial. <strong><span style=\"color: #ff0000;\">By showing that neurons in our task represent remote locations rather than the subject\u2019s own position, our results suggest that the human MTL can represent remote spatial information according to task demands<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Tsitsiklis, Melina, Jonathan Miller, Salman E. Qasim, Cory S. Inman, Robert E. Gross, Jon R. Willie, Elliot H. Smith et al. &#8220;<a href=\"https:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(19)31518-0\"><strong>Single-neuron representations of spatial memory targets in humans<\/strong><\/a>.&#8221;\u00a0<i>BioRxiv<\/i>\u00a0(2019): 523753.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tsitsiklis, Melina, Jonathan Miller, Salman E. Qasim, Cory S. Inman, Robert E. Gross, Jon R. Willie, Elliot H. Smith et al. &#8220;Single-neuron representations of spatial memory targets in humans.&#8221;\u00a0BioRxiv\u00a0(2019): 523753. Highlights \u2022 Epilepsy patients performed a spatial navigation task during single-neuron recordings \u2022 Neuronal firing in the medial temporal lobe represents spatial target locations \u2022 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346,519],"tags":[673,672,358,671],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2166"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2166"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2166\/revisions"}],"predecessor-version":[{"id":2167,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2166\/revisions\/2167"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2166"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}