{"id":2220,"date":"2020-02-01T11:35:14","date_gmt":"2020-02-01T01:35:14","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2220"},"modified":"2020-02-01T11:35:14","modified_gmt":"2020-02-01T01:35:14","slug":"how-is-time-generated-in-the-hippocampal-episodic-memory-system","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2220","title":{"rendered":"How is time generated in the hippocampal episodic memory system?"},"content":{"rendered":"<p style=\"text-align: justify;\">Edmund T. Rolls, Patrick Mills. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124719309398\"><strong>The Generation of Time in the Hippocampal Memory System<\/strong><\/a>. Cell Reports, Volume 28, Issue 7, 2019, Pages 1649-1658.e6.<\/p>\n<p style=\"text-align: justify;\"><strong>In Brief <\/strong><\/p>\n<p style=\"text-align: justify;\">&#8220;Rolls and Mills 2019 <strong><span style=\"color: #ff0000;\">describe a theory and model of how time is generated in the hippocampal episodic memory system<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">Time ramping cells in the lateral entorhinal cortex produce time cells in the hippocampus using a competitive neuronal network architecture<\/span><\/strong>. Forward and reverse replay are emergent properties of the system.&#8221;<\/p>\n<p style=\"text-align: justify;\"><strong>Highlights<\/strong><br \/>\n\u2022 Attractor networks with adaptation form time ramping cells in lateral entorhinal cortex<\/p>\n<p style=\"text-align: justify;\">\u2022 Competitive networks in the hippocampus then generate hippocampal time cells<\/p>\n<p style=\"text-align: justify;\">\u2022 The competitive learning produces sparse representations suitable for memory<\/p>\n<p style=\"text-align: justify;\">\u2022 Forward and reverse replay can arise as emergent properties in this system<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<figure style=\"width: 499px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S2211124719309398-gr1.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S2211124719309398-gr1.jpg\" alt=\"\" width=\"499\" height=\"499\" \/><\/a><figcaption class=\"wp-caption-text\">Model of the Lateral Entorhinal Cortex Temporal Cells and Hippocampal Time Cells<\/figcaption><\/figure>\n<p style=\"text-align: justify;\"><strong>Summary<\/strong><br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">We propose that ramping time cells in the lateral entorhinal cortex can be produced by synaptic adaptation and demonstrate this in an integrate-and-fire attractor network model<\/span><\/strong>. We propose that <strong><span style=\"color: #ff0000;\">competitive networks in the hippocampal system can convert these entorhinal ramping cells into hippocampal time cells and demonstrate this in a competitive network<\/span><\/strong>. We propose that this conversion is necessary to provide <strong><span style=\"color: #ff0000;\">orthogonal hippocampal time representations to encode the temporal sequence of events in hippocampal episodic memory<\/span><\/strong>, and we support that with analytic arguments. We demonstrate that this processing can produce hippocampal neuronal ensembles that not only show replay of the sequence later on, but can also do this in reverse order in reverse replay. <strong><span style=\"color: #ff0000;\">This research addresses a major issue in neuroscience: the mechanisms by which time is encoded in the brain and how the time representations are then useful in the hippocampal memory of events and their order<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Edmund T. Rolls, Patrick Mills. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124719309398\"><strong>The Generation of Time in the Hippocampal Memory System<\/strong><\/a>. Cell Reports, Volume 28, Issue 7, 2019, Pages 1649-1658.e6.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Edmund T. Rolls, Patrick Mills. The Generation of Time in the Hippocampal Memory System. Cell Reports, Volume 28, Issue 7, 2019, Pages 1649-1658.e6. In Brief &#8220;Rolls and Mills 2019 describe a theory and model of how time is generated in the hippocampal episodic memory system. Time ramping cells in the lateral entorhinal cortex produce time [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,636,762],"tags":[169,765,763,205,766,764],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2220"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2220"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2220\/revisions"}],"predecessor-version":[{"id":2221,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2220\/revisions\/2221"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2220"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2220"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}