{"id":2266,"date":"2020-03-11T10:44:51","date_gmt":"2020-03-11T00:44:51","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2266"},"modified":"2020-03-11T10:45:16","modified_gmt":"2020-03-11T00:45:16","slug":"how-does-the-brain-encod-landmarks%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2266","title":{"rendered":"How does the brain encode landmarks\uff1f"},"content":{"rendered":"<p style=\"text-align: justify;\">Fischer, Lukas, Raul Mojica Soto-Albors, Friederike Buck, and Mark Harnett. &#8220;<a href=\"https:\/\/elifesciences.org\/articles\/51458\"><strong>Representation of Visual Landmarks in Retrosplenial Cortex<\/strong><\/a>.&#8221; <span class=\"contextual-data__cite\">eLife 2020;9:e51458<\/span>\u00a0<span class=\"doi\">DOI:\u00a010.7554\/eLife.51458<\/span><\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n &#8220;<span style=\"color: #ff0000;\"><strong>The process by which visual information is incorporated into the brain\u2019s spatial framework to represent landmarks is poorly understood<\/strong><\/span>. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which <strong><span style=\"color: #ff0000;\">head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations<\/span><\/strong>. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling the virtual environment from mouse behavior degraded spatial representations and provided evidence that <strong><span style=\"color: #ff0000;\">supralinear integration of visual and motor inputs contributes to landmark encoding<\/span><\/strong>. V1 axons recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tuning. Our data indicate that<strong><span style=\"color: #ff0000;\"> landmark representations in RSC are the result of local integration of visual, motor, and spatial information<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Fischer, Lukas, Raul Mojica Soto-Albors, Friederike Buck, and Mark Harnett. &#8220;<a href=\"https:\/\/elifesciences.org\/articles\/51458\"><strong>Representation of Visual Landmarks in Retrosplenial Cortex<\/strong><\/a>.&#8221; <span class=\"contextual-data__cite\">eLife 2020;9:e51458<\/span>\u00a0<span class=\"doi\">DOI:\u00a010.7554\/eLife.51458<\/span><\/p>\n<p style=\"text-align: justify;\">Further info:<\/p>\n<p style=\"text-align: justify;\">MIT News <a href=\"http:\/\/news.mit.edu\/2020\/brain-encodes-landmarks-navigate-0310\">How the brain encodes landmarks that help us navigate<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fischer, Lukas, Raul Mojica Soto-Albors, Friederike Buck, and Mark Harnett. &#8220;Representation of Visual Landmarks in Retrosplenial Cortex.&#8221; eLife 2020;9:e51458\u00a0DOI:\u00a010.7554\/eLife.51458 Abstract &#8220;The process by which visual information is incorporated into the brain\u2019s spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,419],"tags":[87,796,797,559],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2266"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2266"}],"version-history":[{"count":3,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2266\/revisions"}],"predecessor-version":[{"id":2269,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2266\/revisions\/2269"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}