{"id":2321,"date":"2020-08-22T11:19:11","date_gmt":"2020-08-22T01:19:11","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2321"},"modified":"2020-08-22T11:19:11","modified_gmt":"2020-08-22T01:19:11","slug":"how-is-information-about-position-direction-of-motion-and-speed-represented-in-the-hippocampus","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2321","title":{"rendered":"How  is information about position, direction of motion, and speed represented in the hippocampus?"},"content":{"rendered":"<p style=\"text-align: justify;\">Stefanini, Fabio, Lyudmila Kushnir, Jessica C. Jimenez, Joshua H. Jennings, Nicholas I. Woods, Garret D. Stuber, Mazen A. Kheirbek, Ren\u00e9 Hen, and Stefano Fusi. &#8220;<a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(20)30391-3\"><strong>A distributed neural code in the dentate gyrus and in CA1<\/strong><\/a>.&#8221; Neuron (2020), Volume 107, Issue 4, 19 August 2020, Pages 703-716.e4<\/p>\n<p style=\"text-align: justify;\">In Brief<br \/>\n&#8220;Using high-resolution calcium imaging and machine learning techniques, <strong><span style=\"color: #ff0000;\">Stefanini et al. studied how information<\/span><\/strong><br \/>\n<span style=\"color: #ff0000;\"><strong>about position, direction of motion, and speed is represented in the<\/strong> <strong>hippocampus<\/strong><\/span>. They show that <strong><span style=\"color: #ff0000;\">neurons cooperate to encode this information<\/span><\/strong>, and that cells with easily interpretable responses are not necessarily the most important ones.&#8221;<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n&#8220;Neurons are often considered specialized functional units that encode a single variable. However, many neurons are observed to respond to a mix of disparate sensory, cognitive, and behavioral variables. For such representations, information is distributed across multiple neurons. Here we find this distributed code in the dentate gyrus and CA1 subregions of the hippocampus. <strong><span style=\"color: #ff0000;\">Using calcium imaging in freely moving mice, we decoded an animal\u2019s position, direction of motion, and speed from the activity of hundreds of cells.<\/span><\/strong> The response properties of individual neurons were only partially predictive of their importance for encoding position. <strong><span style=\"color: #ff0000;\">Non-place cells encoded position and contributed to position encoding when combined with other cells.<\/span><\/strong> Indeed, disrupting the correlations between neural activities decreased decoding performance, mostly in CA1. <strong><span style=\"color: #ff0000;\">Our analysis indicates that population methods rather than classical analyses based on single-cell response properties may more accurately characterize the neural code in the hippocampus<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Stefanini, Fabio, Lyudmila Kushnir, Jessica C. Jimenez, Joshua H. Jennings, Nicholas I. Woods, Garret D. Stuber, Mazen A. Kheirbek, Ren\u00e9 Hen, and Stefano Fusi. &#8220;<a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(20)30391-3\"><strong>A distributed neural code in the dentate gyrus and in CA1<\/strong><\/a>.&#8221; Neuron (2020), Volume 107, Issue 4, 19 August 2020, Pages 703-716.e4<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stefanini, Fabio, Lyudmila Kushnir, Jessica C. Jimenez, Joshua H. Jennings, Nicholas I. Woods, Garret D. Stuber, Mazen A. Kheirbek, Ren\u00e9 Hen, and Stefano Fusi. &#8220;A distributed neural code in the dentate gyrus and in CA1.&#8221; Neuron (2020), Volume 107, Issue 4, 19 August 2020, Pages 703-716.e4 In Brief &#8220;Using high-resolution calcium imaging and machine learning [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,419],"tags":[750,655,827,630],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2321"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2321"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2321\/revisions"}],"predecessor-version":[{"id":2322,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2321\/revisions\/2322"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}