{"id":2385,"date":"2020-12-30T14:45:10","date_gmt":"2020-12-30T04:45:10","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2385"},"modified":"2020-12-30T14:45:10","modified_gmt":"2020-12-30T04:45:10","slug":"how-do-hippocampal-replay-patterns-dynamically-change-during-the-spatial-learning-process","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2385","title":{"rendered":"How do hippocampal replay patterns dynamically change during the spatial learning process"},"content":{"rendered":"<p style=\"text-align: justify;\">Hideyoshi Igata, Yuji Ikegaya, Takuya Sasaki. <a href=\"https:\/\/www.pnas.org\/content\/118\/1\/e2011266118\"><strong>Prioritized experience replays on a hippocampal predictive map for learning<\/strong><\/a>. Proceedings of the National Academy of Sciences Jan 2021, 118 (1) e2011266118; DOI: 10.1073\/pnas.2011266118<\/p>\n<p style=\"text-align: justify;\"><strong>Significance<\/strong><\/p>\n<p style=\"text-align: justify;\">\u201c<span style=\"color: #ff0000;\"><strong>The hippocampus is crucial for spatial learning but their neuronal mechanisms remain unknown<\/strong>.<\/span> Here, we found that hippocampal cell ensembles preferentially replayed salient reward-related locations as rats learned a new behavioral trajectory for reward. The contents of these hippocampal replays progressively varied with learning. <strong><span style=\"color: #ff0000;\">Especially during learning, hippocampal neurons even replayed an optimized path that had never been exploited by the animals<\/span><\/strong>. The learning-related hippocampal activity was necessary for the stabilization of spatial behavior. <strong><span style=\"color: #ff0000;\">These results suggest prioritized replays of significant experiences on a predictive map by hippocampal neurons<\/span><\/strong>.\u201c<\/p>\n<p style=\"text-align: justify;\">\nAbstract<\/p>\n<p style=\"text-align: justify;\">\u201cHippocampal cells are central to spatial and predictive representations, and experience replays by place cells are crucial for learning and memory. Nonetheless, <strong><span style=\"color: #ff0000;\">how hippocampal replay patterns dynamically change during the learning process remains to be elucidated<\/span><\/strong>. Here, we designed a spatial task in which rats learned a new behavioral trajectory for reward. We found that as rats updated their behavioral strategies for a novel salient location, hippocampal cell ensembles increased theta-sequences and sharp wave ripple-associated synchronous spikes that preferentially replayed salient locations and reward-related contexts in reverse order. <strong><span style=\"color: #ff0000;\">The directionality and contents of the replays progressively varied with learning, including an optimized path that had never been exploited by the animals, suggesting prioritized replays of significant experiences on a predictive map<\/span><\/strong>. Online feedback blockade of sharp wave ripples during a learning process inhibited stabilizing optimized behavior. <span style=\"color: #ff0000;\"><strong>These results implicate learning-associated experience replays that act to learn and reinforce specific behavioral strategies<\/strong><\/span>.\u201c<\/p>\n<p style=\"text-align: justify;\">Hideyoshi Igata, Yuji Ikegaya, Takuya Sasaki. <a href=\"https:\/\/www.pnas.org\/content\/118\/1\/e2011266118\"><strong>Prioritized experience replays on a hippocampal predictive map for learning<\/strong><\/a>. Proceedings of the National Academy of Sciences Jan 2021, 118 (1) e2011266118; DOI: 10.1073\/pnas.2011266118<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hideyoshi Igata, Yuji Ikegaya, Takuya Sasaki. Prioritized experience replays on a hippocampal predictive map for learning. Proceedings of the National Academy of Sciences Jan 2021, 118 (1) e2011266118; DOI: 10.1073\/pnas.2011266118 Significance \u201cThe hippocampus is crucial for spatial learning but their neuronal mechanisms remain unknown. Here, we found that hippocampal cell ensembles preferentially replayed salient reward-related [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,519],"tags":[875,876,877,878,704,148,358],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2385"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2385"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2385\/revisions"}],"predecessor-version":[{"id":2386,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2385\/revisions\/2386"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2385"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2385"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2385"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}