{"id":2415,"date":"2021-05-10T20:09:26","date_gmt":"2021-05-10T10:09:26","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2415"},"modified":"2021-05-10T20:09:26","modified_gmt":"2021-05-10T10:09:26","slug":"how-does-mice-learn-multi-step-routes-by-memorizing-subgoal-locations","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2415","title":{"rendered":"How does mice learn multi-step routes by memorizing subgoal locations?"},"content":{"rendered":"<p style=\"text-align: justify;\">Philip Shamash, Sarah F. Olesen, Panagiota Iordanidou, Dario Campagner, Nabhojit Banerjee, Tiago Branco. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.08.19.256867v2\"><strong>Mice learn multi-step routes by memorizing subgoal locations<\/strong><\/a>.\u00a0 bioRxiv 2020.08.19.256867; doi: https:\/\/doi.org\/10.1101\/2020.08.19.256867<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">The behavioral strategies that mammals use to learn multi-step routes in natural settings are unknown.<\/span><\/strong> Here we show that <strong><span style=\"color: #ff0000;\">mice spontaneously adopt a subgoal memory strategy<\/span><\/strong>. We first investigated <strong><span style=\"color: #ff0000;\">how mice navigate to shelter in response to threats when the direct path is blocked<\/span><\/strong>. Initially, <strong><span style=\"color: #ff0000;\">they fled toward the shelter and negotiated obstacles using sensory cue<\/span><\/strong>s. Within twenty minutes, they adopted a subgoal strategy, initiating escapes by running directly to the obstacle&#8217;s edge. <strong><span style=\"color: #ff0000;\">Mice continued to target this subgoal location after the obstacle was removed<\/span><\/strong>, <strong><span style=\"color: #ff0000;\">indicating use of spatial memory<\/span><\/strong>. However, standard models of spatial learning &#8211; egocentric-movement repetition and internal-map building &#8211; did not explain <strong><span style=\"color: #ff0000;\">how subgoal memories formed<\/span><\/strong>. Instead, mice used a hybrid approach: memorizing salient locations encountered during spontaneous &#8216;practice runs&#8217;. This strategy was also used during geometrically identical reward-seeking behavior. <span style=\"color: #ff0000;\"><strong>These results suggest that subgoal memorization is a fundamental strategy by which rodents learn efficient multi-step routes in new environments.<\/strong><\/span>&#8220;<\/p>\n<p style=\"text-align: justify;\">Philip Shamash, Sarah F. Olesen, Panagiota Iordanidou, Dario Campagner, Nabhojit Banerjee, Tiago Branco. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.08.19.256867v2\"><strong>Mice learn multi-step routes by memorizing subgoal locations<\/strong><\/a>.\u00a0 bioRxiv 2020.08.19.256867; doi: https:\/\/doi.org\/10.1101\/2020.08.19.256867<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Philip Shamash, Sarah F. Olesen, Panagiota Iordanidou, Dario Campagner, Nabhojit Banerjee, Tiago Branco. Mice learn multi-step routes by memorizing subgoal locations.\u00a0 bioRxiv 2020.08.19.256867; doi: https:\/\/doi.org\/10.1101\/2020.08.19.256867 Abstract &#8220;The behavioral strategies that mammals use to learn multi-step routes in natural settings are unknown. Here we show that mice spontaneously adopt a subgoal memory strategy. We first investigated [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,519],"tags":[148,825,826],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2415"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2415"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2415\/revisions"}],"predecessor-version":[{"id":2416,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2415\/revisions\/2416"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}