{"id":2424,"date":"2021-05-26T11:23:59","date_gmt":"2021-05-26T01:23:59","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2424"},"modified":"2021-05-26T11:23:59","modified_gmt":"2021-05-26T01:23:59","slug":"how-do-hippocampal-individual-neurons-combine-multiple-features-of-the-navigation-experience-encoding-a-mixed-representation-of-position-head-direction-and-speed","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2424","title":{"rendered":"How do hippocampal individual neurons combine multiple features of the navigation experience, encoding a mixed representation of position, head direction, and speed?"},"content":{"rendered":"<p style=\"text-align: justify;\">Ledergerber, Debora, Claudia Battistin, Jan Sigurd Blackstad, Richard J. Gardner, Menno P. Witter, May-Britt Moser, Yasser Roudi, and Edvard I. Moser. &#8220;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124721005209?via%3Dihub\"><strong>Task-dependent mixed selectivity in the subiculum<\/strong><\/a>.&#8221; Cell Report, Volume 35, Issue 8, 25 May 2021, 109175.\u00a0<\/p>\n<p style=\"text-align: justify;\">Highlights<br \/>\n\u2022 CA1 and subiculum neurons respond conjunctively to position, head direction, and speed<\/p>\n<p style=\"text-align: justify;\">\u2022 The degree of conjunctive coding (\u201cmixed selectivity\u201d) is stronger in the subiculum<\/p>\n<p style=\"text-align: justify;\">\u2022 Mixed selectivity is stronger during goal-directed navigation than in free foraging<\/p>\n<p style=\"text-align: justify;\">\u2022 Decoding of each navigational covariate is more accurate with mixed selectivity<\/p>\n<p style=\"text-align: justify;\">\nSummary<br \/>\n&#8220;CA1 and subiculum (SUB) connect the hippocampus to numerous output regions. Cells in both areas have place-specific firing fields, although they are more dispersed in SUB. Weak responses to head direction and running speed have been reported in both regions. However, <span style=\"color: #ff0000;\"><strong>how such information is encoded in CA1 and SUB and the resulting impact on downstream targets are poorly understood<\/strong><\/span>. Here, <strong><span style=\"color: #ff0000;\">we estimate the tuning of simultaneously recorded CA1 and SUB cells to position, head direction, and speed<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">Individual neurons respond conjunctively to these covariates in both regions<\/span><\/strong>, but the degree of mixed representation is stronger in SUB, and more so during goal-directed spatial navigation than free foraging. Each navigational variable could be decoded with higher precision, from a similar number of neurons, in SUB than CA1. <strong><span style=\"color: #ff0000;\">The findings point to a possible contribution of mixed-selective coding in SUB to efficient transmission of hippocampal representations to widespread brain regions<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Ledergerber, Debora, Claudia Battistin, Jan Sigurd Blackstad, Richard J. Gardner, Menno P. Witter, May-Britt Moser, Yasser Roudi, and Edvard I. Moser. &#8220;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124721005209?via%3Dihub\"><strong>Task-dependent mixed selectivity in the subiculum<\/strong><\/a>.&#8221; Cell Report, Volume 35, Issue 8, 25 May 2021, 109175.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ledergerber, Debora, Claudia Battistin, Jan Sigurd Blackstad, Richard J. Gardner, Menno P. Witter, May-Britt Moser, Yasser Roudi, and Edvard I. Moser. &#8220;Task-dependent mixed selectivity in the subiculum.&#8221; Cell Report, Volume 35, Issue 8, 25 May 2021, 109175.\u00a0 Highlights \u2022 CA1 and subiculum neurons respond conjunctively to position, head direction, and speed \u2022 The degree of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[901,253,904,175,630,902,903],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2424"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2424"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2424\/revisions"}],"predecessor-version":[{"id":2425,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2424\/revisions\/2425"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2424"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2424"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}