{"id":2509,"date":"2021-12-08T11:34:15","date_gmt":"2021-12-08T01:34:15","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2509"},"modified":"2021-12-08T11:34:15","modified_gmt":"2021-12-08T01:34:15","slug":"how-do-sensory-neurons-adapt-at-the-longer-timescales-over-which-animals-traverse-different-environments","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2509","title":{"rendered":"How do sensory neurons adapt at the longer timescales over which animals traverse different environments?"},"content":{"rendered":"<p style=\"text-align: justify;\">Tatsuya Tsukahara, David H. Brann, Stan L. Pashkovski, Grigori Guitchounts, Thomas Bozza, Sandeep Robert Datta. <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(21)01337-4\"><strong>A transcriptional rheostat couples past activity to future sensory responses<\/strong><\/a>. Cell, December 07, 2021, DOI:https:\/\/doi.org\/10.1016\/j.cell.2021.11.022<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n&#8220;<span style=\"color: #ff0000;\">Animals traversing different environments encounter both stable background stimuli and novel cues, which are thought to be detected by primary sensory neurons and then distinguished by downstream brain circuits<\/span>. Here, we show that each of the \u223c1,000 olfactory sensory neuron (OSN) subtypes in the mouse harbors a distinct transcriptome whose content is precisely determined by interactions between its odorant receptor and the environment. This transcriptional variation is systematically organized to support sensory adaptation: expression levels of more than 70 genes relevant to transforming odors into spikes continuously vary across OSN subtypes, dynamically adjust to new environments over hours, and accurately predict acute OSN-specific odor responses. <span style=\"color: #ff0000;\">The sensory periphery therefore separates salient signals from predictable background via a transcriptional rheostat whose moment-to-moment state reflects the past and constrains the future<\/span>; these findings <strong><span style=\"color: #ff0000;\">suggest a general model in which structured transcriptional variation within a cell type reflects individual experience<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Tatsuya Tsukahara, David H. Brann, Stan L. Pashkovski, Grigori Guitchounts, Thomas Bozza, Sandeep Robert Datta. <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(21)01337-4\"><strong>A transcriptional rheostat couples past activity to future sensory responses<\/strong><\/a>. Cell, December 07, 2021, DOI:https:\/\/doi.org\/10.1016\/j.cell.2021.11.022<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tatsuya Tsukahara, David H. Brann, Stan L. Pashkovski, Grigori Guitchounts, Thomas Bozza, Sandeep Robert Datta. A transcriptional rheostat couples past activity to future sensory responses. Cell, December 07, 2021, DOI:https:\/\/doi.org\/10.1016\/j.cell.2021.11.022 Summary &#8220;Animals traversing different environments encounter both stable background stimuli and novel cues, which are thought to be detected by primary sensory neurons and then [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,419],"tags":[944,680],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2509"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2509"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2509\/revisions"}],"predecessor-version":[{"id":2510,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2509\/revisions\/2510"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2509"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2509"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}