{"id":2526,"date":"2022-01-13T11:04:38","date_gmt":"2022-01-13T01:04:38","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2526"},"modified":"2022-01-13T13:07:31","modified_gmt":"2022-01-13T03:07:31","slug":"whether-grid-cell-networks-show-continuous-attractor-dynamics-and-how-they-interface-with-inputs-from-the-environment-2","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2526","title":{"rendered":"Whether grid cell networks show continuous attractor dynamics, and how they interface with inputs from the environment?"},"content":{"rendered":"

Richard J. Gardner, Erik Hermansen, Marius Pachitariu, Yoram Burak, Nils A. Baas, Benjamin A. Dunn, May-Britt Moser & Edvard I. Moser.\u00a0Toroidal topology of population activity in grid cells<\/strong><\/a>.\u00a0Nature\u00a0(2022). https:\/\/doi.org\/10.1038\/s41586-021-04268-7<\/p>\n

Abstract
\n “The medial entorhinal cortex is part of a neural system for mapping the position of an individual within a physical environment1. Grid cells, a key component of this system, fire in a characteristic hexagonal pattern of locations2, and are organized in modules3 that collectively form a population code for the animal\u2019s allocentric position<\/span><\/strong>1. The invariance of the correlation structure of this population code across environments4,5 and behavioural states6,7, independent of specific sensory inputs, has pointed to intrinsic, recurrently connected continuous attractor networks (CANs) as a possible substrate of the grid pattern1,8,9,10,11. However, whether grid cell networks show continuous attractor dynamics, and how they interface with inputs from the environment, has remained unclear owing to the small samples of cells obtained so far.<\/span><\/strong> Here, using simultaneous recordings from many hundreds of grid cells and subsequent topological data analysis, we show that the joint activity of grid cells from an individual module resides on a toroidal manifold, as expected in a two-dimensional CAN<\/span><\/strong>. Positions on the torus correspond to positions of the moving animal in the environment. Individual cells are preferentially active at singular positions on the torus. Their positions are maintained between environments and from wakefulness to sleep, as predicted by CAN models for grid cells but not by alternative feedforward models12. This demonstration of network dynamics on a toroidal manifold provides a population-level visualization of CAN dynamics in grid cells.<\/span><\/strong>“<\/p>\n

Questions:<\/p>\n

\u201cWhat kind of network architecture keeps the activity on a toroidal\u00a0manifold\u2014whether it is geometrically organized<\/span>1,8\u201310 <\/span>or acquired from\u00a0random connectivity by synaptic weight adjustments through learning<\/span>39\u201341<\/span>\u2014remains to be determined, as does the mode of connectivity\u00a0with other CANs in the entorhinal\u2013hippocampal system<\/span>22,23<\/span><\/strong><\/span>.<\/strong><\/span>\u00a0<\/span>\u201d<\/p>\n

Richard J. Gardner, Erik Hermansen, Marius Pachitariu, Yoram Burak, Nils A. Baas, Benjamin A. Dunn, May-Britt Moser & Edvard I. Moser.\u00a0Toroidal topology of population activity in grid cells<\/strong><\/a>.\u00a0Nature\u00a0(2022). https:\/\/doi.org\/10.1038\/s41586-021-04268-7<\/p>\n

News:\u00a0Nobel Prize winners with new breakthrough: It has taken almost 30 years to find answers.\u00a0<\/a><\/p>\n

Code:\u00a0https:\/\/github.com\/erikher\/GridCellTorus<\/a>\u00a0<\/p>\n

Datasets:\u00a0https:\/\/figshare.com\/articles\/dataset\/Toroidal_topology_of_population_activity_in_grid_cells\/16764508<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Richard J. Gardner, Erik Hermansen, Marius Pachitariu, Yoram Burak, Nils A. Baas, Benjamin A. Dunn, May-Britt Moser & Edvard I. Moser.\u00a0Toroidal topology of population activity in grid cells.\u00a0Nature\u00a0(2022). https:\/\/doi.org\/10.1038\/s41586-021-04268-7 Abstract “The medial entorhinal cortex is part of a neural system for mapping the position of an individual within a physical environment1. Grid cells, a key […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[251,218,103,951],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2526"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2526"}],"version-history":[{"count":5,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2526\/revisions"}],"predecessor-version":[{"id":2534,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2526\/revisions\/2534"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}