{"id":2537,"date":"2022-01-17T11:12:40","date_gmt":"2022-01-17T01:12:40","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2537"},"modified":"2022-01-17T11:12:40","modified_gmt":"2022-01-17T01:12:40","slug":"how-does-the-mammalian-brain-represent-goal-locations","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2537","title":{"rendered":"How does the mammalian brain represent goal locations?"},"content":{"rendered":"<p style=\"text-align: justify;\">Nils Nyberg,\u00a0\u00c9l\u00e9onore Duvelle, Caswell Barry, Hugo J. Spiers. <a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(21)01029-1\"><strong>Spatial goal coding in the hippocampal formation<\/strong><\/a>. Neuron, January 14, 2022. DOI:https:\/\/doi.org\/10.1016\/j.neuron.2021.12.012<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n&#8220;The mammalian hippocampal formation contains several distinct populations of neurons involved in representing self-position and orientation. These neurons, which include place, grid, head direction, and boundary-vector cells, are thought to collectively instantiate cognitive maps supporting flexible navigation. However, <strong><span style=\"color: #ff0000;\">to flexibly navigate, it is necessary to also maintain internal representations of goal locations, such that goal-directed routes can be planned and executed<\/span><\/strong>. Although <strong><span style=\"color: #ff0000;\">it has remained unclear how the mammalian brain represents goal locations, multiple neural candidates have recently been uncovered during different phases of navigation<\/span><\/strong>. For example, <strong><span style=\"color: #ff0000;\">during planning<\/span><\/strong>, sequential activation of spatial cells may enable simulation of future routes toward the goal. <strong><span style=\"color: #ff0000;\">During travel<\/span><\/strong>, modulation of spatial cells by the prospective route, or by distance and direction to the goal, may allow maintenance of route and goal-location information, supporting navigation on an ongoing basis. <strong><span style=\"color: #ff0000;\">As the goal is approached<\/span><\/strong>, an increased activation of spatial cells may enable the goal location to become distinctly represented within cognitive maps, aiding goal localization. Lastly, <strong><span style=\"color: #ff0000;\">after arrival at the goal<\/span><\/strong>, sequential activation of spatial cells may represent the just-taken route, enabling route learning and evaluation. Here, <strong><span style=\"color: #ff0000;\">we review and synthesize these and other evidence for goal coding in mammalian brains, relate the experimental findings to predictions from computational models, and discuss outstanding questions and future challenges<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Nils Nyberg,\u00a0\u00c9l\u00e9onore Duvelle, Caswell Barry, Hugo J. Spiers. <a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(21)01029-1\"><strong>Spatial goal coding in the hippocampal formation<\/strong><\/a>. Neuron, January 14, 2022. DOI:https:\/\/doi.org\/10.1016\/j.neuron.2021.12.012<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nils Nyberg,\u00a0\u00c9l\u00e9onore Duvelle, Caswell Barry, Hugo J. Spiers. Spatial goal coding in the hippocampal formation. Neuron, January 14, 2022. DOI:https:\/\/doi.org\/10.1016\/j.neuron.2021.12.012 Summary &#8220;The mammalian hippocampal formation contains several distinct populations of neurons involved in representing self-position and orientation. These neurons, which include place, grid, head direction, and boundary-vector cells, are thought to collectively instantiate cognitive maps [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,960,346],"tags":[258,961],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2537"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2537"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2537\/revisions"}],"predecessor-version":[{"id":2538,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2537\/revisions\/2538"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}