{"id":2539,"date":"2022-01-17T12:07:53","date_gmt":"2022-01-17T02:07:53","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2539"},"modified":"2022-01-17T12:07:53","modified_gmt":"2022-01-17T02:07:53","slug":"what-is-the-principle-of-the-functional-circuit-interactions-between-lec-and-the-hippocampus","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2539","title":{"rendered":"What is the principle of the functional circuit interactions between LEC and the hippocampus?"},"content":{"rendered":"<p style=\"text-align: justify;\">Olesia M Bilash, Spyridon Chavlis, Panayiota Poirazi, Jayeeta Basu. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.01.13.476247v1\"><strong>Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit<\/strong><\/a>.\u00a0bioRxiv 2022.01.13.476247; doi: https:\/\/doi.org\/10.1101\/2022.01.13.476247<\/p>\n<p style=\"text-align: justify;\">\nAbstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">The lateral entorhinal cortex (LEC) provides information about multi-sensory environmental cues to the hippocampus through direct inputs to the distal dendrites of CA1 pyramidal neurons<\/span><\/strong>. A growing body of work suggests that LEC neurons perform important functions for episodic memory processing, coding for contextually-salient elements of an environment or the experience within it. However, <strong><span style=\"color: #ff0000;\">we know little about the functional circuit interactions between LEC and the hippocampus<\/span><\/strong>. In this study, we combine functional circuit mapping and computational modeling to examine <strong><span style=\"color: #ff0000;\">how long-range glutamatergic LEC projections modulate compartment-specific excitation-inhibition dynamics in hippocampal area CA1<\/span><\/strong>. We demonstrate that glutamatergic LEC inputs can drive local dendritic spikes in CA1 pyramidal neurons, aided by the recruitment of a disinhibitory vasoactive intestinal peptide (VIP)-expressing inhibitory neuron microcircuit. Our circuit mapping further reveals that, in parallel, LEC also recruits cholecystokinin (CCK)-expressing inhibitory neurons, which our model predicts act as a strong suppressor of dendritic spikes. <strong><span style=\"color: #ff0000;\">These results provide new insight into a cortically-driven GABAergic microcircuit mechanism that gates non-linear dendritic computations, which may support compartment-specific coding of multi-sensory contextual features within the hippocampus<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Olesia M Bilash, Spyridon Chavlis, Panayiota Poirazi, Jayeeta Basu. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.01.13.476247v1\"><strong>Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit<\/strong><\/a>.\u00a0bioRxiv 2022.01.13.476247; doi: https:\/\/doi.org\/10.1101\/2022.01.13.476247<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Olesia M Bilash, Spyridon Chavlis, Panayiota Poirazi, Jayeeta Basu. Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit.\u00a0bioRxiv 2022.01.13.476247; doi: https:\/\/doi.org\/10.1101\/2022.01.13.476247 Abstract &#8220;The lateral entorhinal cortex (LEC) provides information about multi-sensory environmental cues to the hippocampus through direct inputs to the distal dendrites of CA1 pyramidal neurons. A growing body [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,636,346,519],"tags":[963,349,962,637,362],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2539"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2539"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2539\/revisions"}],"predecessor-version":[{"id":2540,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2539\/revisions\/2540"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}