{"id":2543,"date":"2022-01-18T17:41:28","date_gmt":"2022-01-18T07:41:28","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2543"},"modified":"2022-01-18T17:41:28","modified_gmt":"2022-01-18T07:41:28","slug":"how-does-the-retina-construct-the-distinct-neural-representations-required-for-diverse-behaviors","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2543","title":{"rendered":"How does the retina construct the distinct neural representations required for diverse behaviors?"},"content":{"rendered":"<p style=\"text-align: justify;\">Mathew T. Summers, Marla B. Feller. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.01.13.476257v1\"><strong>Distinct Inhibitory Pathways Control Velocity and Directional Tuning in the Retina<\/strong><\/a>.\u00a0bioRxiv 2022.01.13.476257; doi: https:\/\/doi.org\/10.1101\/2022.01.13.476257<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;The sensory periphery is responsible for detecting ethologically relevant features of the external world, using compact, predominantly feedforward circuits. <strong><span style=\"color: #ff0000;\">Visual motion is a particularly prevalent sensory feature, the presence of which can be a signal to enact diverse behaviors ranging from gaze stabilization reflexes, to predator avoidance or prey capture<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">To understand how the retina constructs the distinct neural representations required for these diverse behaviors, we investigated two circuits responsible for encoding different aspects of image motion: ON and ON-OFF direction selective ganglion cells (DSGCs)<\/span><\/strong>. Using a combination of 2-photon targeted whole cell electrophysiology, pharmacology, and conditional knockout mice,<strong><span style=\"color: #ff0000;\"> we show that distinct inhibitory pathways independently control tuning for motion velocity and motion direction in these two cell types<\/span><\/strong>. We further employ dynamic clamp and numerical modeling techniques to show that asymmetric inhibition provides a velocity-invariant mechanism of directional tuning, despite the strong velocity dependence of classical models of direction selectivity. <strong><span style=\"color: #ff0000;\">We therefore demonstrate that invariant representations of motion features by inhibitory interneurons act as computational building blocks to construct distinct, behaviorally relevant signals at the earliest stages of the visual system<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Mathew T. Summers, Marla B. Feller. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.01.13.476257v1\"><strong>Distinct Inhibitory Pathways Control Velocity and Directional Tuning in the Retina<\/strong><\/a>.\u00a0bioRxiv 2022.01.13.476257; doi: https:\/\/doi.org\/10.1101\/2022.01.13.476257<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mathew T. Summers, Marla B. Feller. Distinct Inhibitory Pathways Control Velocity and Directional Tuning in the Retina.\u00a0bioRxiv 2022.01.13.476257; doi: https:\/\/doi.org\/10.1101\/2022.01.13.476257 Abstract &#8220;The sensory periphery is responsible for detecting ethologically relevant features of the external world, using compact, predominantly feedforward circuits. Visual motion is a particularly prevalent sensory feature, the presence of which can be a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[479,96,346],"tags":[965,966,964,967],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2543"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2543"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2543\/revisions"}],"predecessor-version":[{"id":2544,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2543\/revisions\/2544"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2543"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2543"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}