{"id":2549,"date":"2022-01-27T13:54:18","date_gmt":"2022-01-27T03:54:18","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2549"},"modified":"2022-01-27T13:54:18","modified_gmt":"2022-01-27T03:54:18","slug":"whats-the-role-of-the-orbitofrontal-cortex-in-creating-cognitive-maps","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2549","title":{"rendered":"What&#8217;s the role of the orbitofrontal cortex in creating cognitive maps?"},"content":{"rendered":"<p style=\"text-align: justify;\">Kau\u00ea Machado Costa, Robert Scholz, Kevin Lloyd, Perla Moreno-Castilla, Matthew P.H. Gardner, Peter Dayan, Geoffrey Schoenbaum. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.01.25.477716v1\"><strong>The role of the orbitofrontal cortex in creating cognitive maps<\/strong><\/a>.\u00a0bioRxiv 2022.01.25.477716<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">We use internal models of the external world to guide behavior, but little is known about how these cognitive maps are created.<\/span><\/strong> The orbitofrontal cortex (OFC) is typically thought to access these maps to support model-based decision-making, but it has recently been proposed that its critical contribution may be instead to integrate information into existing and new models. We tested between these alternatives using an outcome-specific devaluation task and a high-potency chemogenetic approach. <span style=\"color: #ff0000;\">We found that selectively inactivating OFC principal neurons when rats learned distinct cue-outcome associations, but prior to outcome devaluation, disrupted subsequent model-based inference, confirming that the OFC is critical for creating new cognitive maps<\/span>. However, OFC inactivation surprisingly led to generalized devaluation. Using a novel reinforcement learning framework, we demonstrate that this effect is best explained not by a switch to a model-free system, as would be traditionally assumed, but rather by a circumscribed deficit in defining credit assignment precision during model construction. <span style=\"color: #ff0000;\">We conclude that the critical contribution of the OFC to learning is regulating the specificity of associations that comprise cognitive maps<\/span>. &#8220;<\/p>\n<p style=\"text-align: justify;\">Kau\u00ea Machado Costa, Robert Scholz, Kevin Lloyd, Perla Moreno-Castilla, Matthew P.H. Gardner, Peter Dayan, Geoffrey Schoenbaum. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.01.25.477716v1\"><strong>The role of the orbitofrontal cortex in creating cognitive maps<\/strong><\/a>.\u00a0bioRxiv 2022.01.25.477716<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kau\u00ea Machado Costa, Robert Scholz, Kevin Lloyd, Perla Moreno-Castilla, Matthew P.H. Gardner, Peter Dayan, Geoffrey Schoenbaum. The role of the orbitofrontal cortex in creating cognitive maps.\u00a0bioRxiv 2022.01.25.477716 Abstract &#8220;We use internal models of the external world to guide behavior, but little is known about how these cognitive maps are created. The orbitofrontal cortex (OFC) is [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[147,971],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2549"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2549"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2549\/revisions"}],"predecessor-version":[{"id":2550,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2549\/revisions\/2550"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2549"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2549"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2549"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}