{"id":2559,"date":"2022-02-10T12:51:41","date_gmt":"2022-02-10T02:51:41","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2559"},"modified":"2022-02-10T12:51:41","modified_gmt":"2022-02-10T02:51:41","slug":"how-information-about-spatial-landmarks-and-movement-is-encoded-in-the-first-stage-of-the-hippocampus-the-dentate-gyrus%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2559","title":{"rendered":"How information about spatial landmarks and movement is encoded in the first stage of the hippocampus, the dentate gyrus\uff1f"},"content":{"rendered":"<p style=\"text-align: justify;\">Sebnem N. Tuncdemir, Andres D. Grosmark, Gergely F. Turi, Amei Shank, John C. Bowler, Gokhan Ordek, Attila Losonczy, Rene Hen, Clay O. Lacefield.\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124721017691\"><strong>Parallel processing of sensory cue and spatial information in the dentate gyrus<\/strong><\/a>.\u00a0Cell Reports, Volume 38, Issue 3, 2022,\u00a0https:\/\/doi.org\/10.1016\/j.celrep.2021.110257.<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n\u201cDuring exploration, animals form an internal map of an environment by combining information about landmarks and the animal\u2019s movement, a process that depends on the hippocampus. <span style=\"color: #ff0000;\"><strong>The dentate gyrus (DG) is the first stage of the hippocampal circuit where self-motion (\u201cwhere\u201d) and sensory cue information (\u201cwhat\u201d) are integrated, but it remains unknown how DG neurons encode this information during cognitive map formation.<\/strong><\/span> Using two-photon calcium imaging in mice running on a treadmill along with online cue manipulation, we identify robust sensory cue responses in DG granule cells. Cue cell responses are stable, stimulus-specific, and accompanied by inhibition of nearby neurons. This demonstrates the existence of \u201ccue cells\u201d in addition to better characterized \u201cplace cells\u201d in the DG. <strong><span style=\"color: #ff0000;\">We hypothesize that the DG supports parallel channels of spatial and non-spatial information that contribute distinctly to downstream computations and affect roles of the DG in spatial navigation and episodic memory<\/span><\/strong>.\u201d<\/p>\n<p style=\"text-align: justify;\">Sebnem N. Tuncdemir, Andres D. Grosmark, Gergely F. Turi, Amei Shank, John C. Bowler, Gokhan Ordek, Attila Losonczy, Rene Hen, Clay O. Lacefield.\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124721017691\"><strong>Parallel processing of sensory cue and spatial information in the dentate gyrus<\/strong><\/a>.\u00a0Cell Reports, Volume 38, Issue 3, 2022,\u00a0https:\/\/doi.org\/10.1016\/j.celrep.2021.110257.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sebnem N. Tuncdemir, Andres D. Grosmark, Gergely F. Turi, Amei Shank, John C. Bowler, Gokhan Ordek, Attila Losonczy, Rene Hen, Clay O. Lacefield.\u00a0Parallel processing of sensory cue and spatial information in the dentate gyrus.\u00a0Cell Reports, Volume 38, Issue 3, 2022,\u00a0https:\/\/doi.org\/10.1016\/j.celrep.2021.110257. Summary \u201cDuring exploration, animals form an internal map of an environment by combining information about [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346,519],"tags":[981,980,821],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2559"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2559"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2559\/revisions"}],"predecessor-version":[{"id":2560,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2559\/revisions\/2560"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2559"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}