{"id":2616,"date":"2022-04-13T17:56:46","date_gmt":"2022-04-13T07:56:46","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2616"},"modified":"2022-04-13T17:56:46","modified_gmt":"2022-04-13T07:56:46","slug":"how-does-the-brain-make-flexible-navigation-decisions-based-on-mixed-visual-and-memory-representations","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2616","title":{"rendered":"How does the brain make flexible navigation decisions based on mixed visual and memory representations?"},"content":{"rendered":"<p style=\"text-align: justify;\">Shinichiro Kira, Houman Safaai, Ari S. Morcos, Stefano Panzeri, Christopher D. Harvey. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.04.10.487349v1.full\"><strong>A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions<\/strong><\/a>. bioRxiv 2022.04.10.487349; doi: https:\/\/doi.org\/10.1101\/2022.04.10.487349<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Decision-making requires flexibility to rapidly switch sensorimotor associations depending on behavioral goals stored in memory<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">We identified cortical areas and neural activity patterns that mediate this flexibility during virtual-navigation, where mice switched navigation toward or away from a visual cue depending on its match to a remembered cue<\/span><\/strong>. An optogenetics screen identified V1, posterior parietal cortex (PPC), and retrosplenial cortex (RSC) as necessary for accurate decisions. Calcium imaging revealed neurons that can mediate rapid sensorimotor switching by encoding a conjunction of a current and remembered visual cue that predicted the mouse\u2019s navigational choice from trial-to-trial. Their activity formed efficient population codes before correct, but not incorrect, choices. These neurons were distributed across posterior cortex, even V1, but were densest in RSC and sparsest in PPC. <strong><span style=\"color: #ff0000;\">We propose the flexibility of navigation decisions arises from neurons that mix visual and memory information within a visual-parietal-retrosplenial network, centered in RSC<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Shinichiro Kira, Houman Safaai, Ari S. Morcos, Stefano Panzeri, Christopher D. Harvey. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.04.10.487349v1.full\"><strong>A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions<\/strong><\/a>. bioRxiv 2022.04.10.487349; doi: https:\/\/doi.org\/10.1101\/2022.04.10.487349<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shinichiro Kira, Houman Safaai, Ari S. Morcos, Stefano Panzeri, Christopher D. Harvey. A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions. bioRxiv 2022.04.10.487349; doi: https:\/\/doi.org\/10.1101\/2022.04.10.487349 Abstract &#8220;Decision-making requires flexibility to rapidly switch sensorimotor associations depending on behavioral goals stored in memory. We identified cortical areas and neural activity patterns that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346],"tags":[148,1004,946],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2616"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2616"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2616\/revisions"}],"predecessor-version":[{"id":2617,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2616\/revisions\/2617"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2616"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2616"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}