{"id":2635,"date":"2022-05-20T14:12:00","date_gmt":"2022-05-20T04:12:00","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2635"},"modified":"2022-05-20T14:12:00","modified_gmt":"2022-05-20T04:12:00","slug":"how-can-a-joint-spatiotemporal-phase-code-implement-the-combined-neural-representation-of-space-and-time-in-the-human-entorhinal-cortex","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2635","title":{"rendered":"How can a joint spatiotemporal phase code implement the combined neural representation of space and time in the human entorhinal cortex?"},"content":{"rendered":"<p style=\"text-align: justify;\">Nadasdy, Z., Howell, D., T\u00f6r\u00f6k, \u00c1., Nguyen, T. P., Shen, J. Y., Briggs, D. E., Modur, P. N., &amp; Buchanan, R. J. (2022). <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abm6081\"><strong>Phase coding of spatial representations in the human entorhinal cortex<\/strong><\/a>.\u00a0<i>Science advances<\/i>,\u00a0<i>8<\/i>(18), eabm6081. https:\/\/doi.org\/10.1126\/sciadv.abm6081<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;The grid-like activity pattern of cells in the mammalian entorhinal cortex provides an internal reference frame for allocentric self-localization. The same neurons maintain robust phase couplings with local field oscillations. <strong><span style=\"color: #ff0000;\">We found that neurons of the human entorhinal cortex display consistent spatial and temporal phase locking between spikes and slow gamma band local field potentials (LFPs) during virtual navigation<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">The phase locking maintained an environment-specific map over time<\/span><\/strong>. The phase tuning of spikes to the slow gamma band LFP revealed spatially periodic phase grids with environment-dependent scaling and consistent alignment with the environment. Using a Bayesian decoding model, we could predict the avatar\u2019s position with near perfect accuracy and, to a lesser extent, that of heading direction as well. <strong><span style=\"color: #ff0000;\">These results imply that the phase of spikes relative to spatially modulated gamma oscillations encode allocentric spatial positions<\/span><\/strong>. We posit that a joint spatiotemporal phase code can implement the combined neural representation of space and time in the human entorhinal cortex.&#8221;<\/p>\n<p style=\"text-align: justify;\">Nadasdy, Z., Howell, D., T\u00f6r\u00f6k, \u00c1., Nguyen, T. P., Shen, J. Y., Briggs, D. E., Modur, P. N., &amp; Buchanan, R. J. (2022). <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abm6081\"><strong>Phase coding of spatial representations in the human entorhinal cortex<\/strong><\/a>.\u00a0<i>Science advances<\/i>,\u00a0<i>8<\/i>(18), eabm6081. https:\/\/doi.org\/10.1126\/sciadv.abm6081<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nadasdy, Z., Howell, D., T\u00f6r\u00f6k, \u00c1., Nguyen, T. P., Shen, J. Y., Briggs, D. E., Modur, P. N., &amp; Buchanan, R. J. (2022). Phase coding of spatial representations in the human entorhinal cortex.\u00a0Science advances,\u00a08(18), eabm6081. https:\/\/doi.org\/10.1126\/sciadv.abm6081 Abstract &#8220;The grid-like activity pattern of cells in the mammalian entorhinal cortex provides an internal reference frame for allocentric [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346],"tags":[223,1018,375],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2635"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2635"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2635\/revisions"}],"predecessor-version":[{"id":2636,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2635\/revisions\/2636"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}