{"id":2657,"date":"2022-07-10T16:46:24","date_gmt":"2022-07-10T06:46:24","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2657"},"modified":"2022-07-10T16:46:24","modified_gmt":"2022-07-10T06:46:24","slug":"how-the-brain-associate-multiple-sensory-cues-with-objects-and-experience","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2657","title":{"rendered":"How the brain associate multiple sensory cues with objects and experience?"},"content":{"rendered":"<p style=\"text-align: justify;\">Scott Waddell, Zeynep Okray, Pedro F Jacob, Ciara Stern, Kieran Desmond, Nils Otto, Paola Vargas-Gutierrez. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.07.08.499174v1\"><strong>Multisensory learning binds modality-specific neurons into a cross-modal memory engram<\/strong><\/a>.\u00a0bioRxiv 2022.07.08.499174; doi: https:\/\/doi.org\/10.1101\/2022.07.08.499174<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Associating multiple sensory cues with objects and experience is a fundamental brain process that improves object recognition and memory performance<\/span><\/strong>. However, <span style=\"color: #ff0000;\"><strong>neural mechanisms that bind sensory features during learning and augment memory expression are unknown<\/strong><\/span>. Here we demonstrate multisensory appetitive and aversive memory in Drosophila. <strong><span style=\"color: #ff0000;\">Combining colors and odors improved memory performance, even when each sensory modality was tested alone<\/span><\/strong>. Temporal control of neuronal function revealed visually-selective mushroom body Kenyon Cells (KCs) to be required for both enhancement of visual and olfactory memory after multisensory training. Voltage imaging in head-fixed flies showed that multisensory learning binds activity between streams of modality-specific KCs, so that unimodal sensory input generates a multimodal neuronal response. Binding occurs between regions of the olfactory and visual KC axons, which receive valence-relevant dopaminergic reinforcement, and is propagated downstream. Dopamine locally releases GABA-ergic inhibition to permit specific microcircuits within KC-spanning serotonergic neurons to function as an excitatory bridge between the previously modality-selective KC streams. <strong><span style=\"color: #ff0000;\">Cross-modal binding thereby expands the olfactory memory engram by recruiting visual path KCs to become odor responsive<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">This broadening of the engram improves memory performance after multisensory learning and permits a single sensory feature to retrieve the memory of the multimodal experience<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Scott Waddell, Zeynep Okray, Pedro F Jacob, Ciara Stern, Kieran Desmond, Nils Otto, Paola Vargas-Gutierrez. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.07.08.499174v1\"><strong>Multisensory learning binds modality-specific neurons into a cross-modal memory engram<\/strong><\/a>.\u00a0bioRxiv 2022.07.08.499174; doi: https:\/\/doi.org\/10.1101\/2022.07.08.499174<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scott Waddell, Zeynep Okray, Pedro F Jacob, Ciara Stern, Kieran Desmond, Nils Otto, Paola Vargas-Gutierrez. Multisensory learning binds modality-specific neurons into a cross-modal memory engram.\u00a0bioRxiv 2022.07.08.499174; doi: https:\/\/doi.org\/10.1101\/2022.07.08.499174 Abstract &#8220;Associating multiple sensory cues with objects and experience is a fundamental brain process that improves object recognition and memory performance. However, neural mechanisms that bind sensory [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,519],"tags":[1034,1036,1035,1033],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2657"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2657"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2657\/revisions"}],"predecessor-version":[{"id":2658,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2657\/revisions\/2658"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2657"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}