{"id":2659,"date":"2022-07-11T12:09:40","date_gmt":"2022-07-11T02:09:40","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2659"},"modified":"2022-07-11T12:09:49","modified_gmt":"2022-07-11T02:09:49","slug":"how-conjunctive-and-complementary-ca1-hippocampal-cell-populations-relate-sensory-events-to-immobility-and-locomotion","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2659","title":{"rendered":"How conjunctive and complementary CA1 hippocampal cell populations relate sensory events to immobility and locomotion?"},"content":{"rendered":"<p style=\"text-align: justify;\">Samsoon Inayat, Brendan B McAllister, Bruce L McNaughton, Ian Q Whishaw, Majid H Mohajerani. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.07.06.498996v1\"><strong>Conjunctive and complementary CA1 hippocampal cell populations relate sensory events to immobility and locomotion<\/strong><\/a>.\u00a0bioRxiv 2022.07.06.498996; doi: https:\/\/doi.org\/10.1101\/2022.07.06.498996<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n &#8220;<strong><span style=\"color: #ff0000;\">The way in which the brain decodes signals from sensory activity related to ongoing behavior has revolutionized the understanding of the function of neocortical areas and provides a blueprint to address allocortical regions such as the hippocampus<\/span><\/strong>. Here two-photon calcium imaging of somal activity in hippocampal CA1 neuron populations was done in head fixed mice given air or light stimulation when at rest or when moving on a conveyor belt. Air stimulation was also used to induce running for a fixed distance on the conveyor belt by releasing a conveyor belt brake. <strong><span style=\"color: #ff0000;\">Overall, 99% of 2083 cells were active across 20 sensorimotor events with a larger proportion of cells active during locomotion.<\/span><\/strong> Nevertheless, for any sensorimotor event, only about 17% cells were active comprising of conjunctive (C \u2208 A and B) cells shared among events and complementary (C \u2208 A not B or C \u2208 B not A) cells active in individual events. <strong><span style=\"color: #ff0000;\">Conjunctive cells identified similar sensorimotor events representing stable representations of familiar experiences and complementary cells suggested recruitment of new cells for encoding novel experiences.<\/span> <span style=\"color: #ff0000;\">The moment-to-moment recruitment of complementary and conjunctive cells with changing sensorimotor events signifies the involvement of hippocampus in functional networks integrating sensory information with ongoing movement<\/span><\/strong>. This role of hippocampus is well suited for movement <strong><span style=\"color: #ff0000;\">guidance, spatial behavior, episodic learning and memory, context representation and scene construction<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Samsoon Inayat, Brendan B McAllister, Bruce L McNaughton, Ian Q Whishaw, Majid H Mohajerani. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.07.06.498996v1\"><strong>Conjunctive and complementary CA1 hippocampal cell populations relate sensory events to immobility and locomotion<\/strong><\/a>.\u00a0bioRxiv 2022.07.06.498996; doi: https:\/\/doi.org\/10.1101\/2022.07.06.498996<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Samsoon Inayat, Brendan B McAllister, Bruce L McNaughton, Ian Q Whishaw, Majid H Mohajerani. Conjunctive and complementary CA1 hippocampal cell populations relate sensory events to immobility and locomotion.\u00a0bioRxiv 2022.07.06.498996; doi: https:\/\/doi.org\/10.1101\/2022.07.06.498996 Abstract &#8220;The way in which the brain decodes signals from sensory activity related to ongoing behavior has revolutionized the understanding of the function of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,636,519],"tags":[901,791,1037,1039,721,1038],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2659"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2659"}],"version-history":[{"count":2,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2659\/revisions"}],"predecessor-version":[{"id":2661,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2659\/revisions\/2661"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2659"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}