{"id":2667,"date":"2022-08-10T10:21:40","date_gmt":"2022-08-10T00:21:40","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2667"},"modified":"2022-08-10T10:21:40","modified_gmt":"2022-08-10T00:21:40","slug":"where-and-how-odor-and-wind-cues-are-integrated-to-support-wind-guided-olfactory-navigation","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2667","title":{"rendered":"Where and how odor and wind cues are integrated to support wind-guided olfactory navigation?"},"content":{"rendered":"<p style=\"text-align: justify;\">Andrew M. M. Matheson, Aaron J. Lanz, Ashley M. Medina, Al M. Licata, Timothy A. Currier, Mubarak H. Syed &amp; Katherine I. Nagel. <a href=\"https:\/\/www.nature.com\/articles\/s41467-022-32247-7\"><strong>A neural circuit for wind-guided olfactory navigation<\/strong><\/a>. Nat Commun 13, 4613 (2022). https:\/\/doi.org\/10.1038\/s41467-022-32247-7<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">To navigate towards a food source, animals frequently combine odor cues about source identity with wind direction cues about source location. Where and how these two cues are integrated to support navigation is unclear.<\/span><\/strong> Here <strong><span style=\"color: #ff0000;\">we describe a pathway to the Drosophila fan-shaped body that encodes attractive odor and promotes upwind navigation<\/span><\/strong>. We show that neurons throughout this pathway encode odor, but not wind direction. Using connectomics, we identify fan-shaped body local neurons called h\u2206C that receive input from this odor pathway and a previously described wind pathway. We show that h\u2206C neurons exhibit odor-gated, wind direction-tuned activity, that sparse activation of h\u2206C neurons promotes navigation in a reproducible direction, and that h\u2206C activity is required for persistent upwind orientation during odor. Based on connectome data, <strong><span style=\"color: #ff0000;\">we develop a computational model showing how h\u2206C activity can promote navigation towards a goal such as an upwind odor source<\/span><\/strong>. Our results suggest that <strong><span style=\"color: #ff0000;\">odor and wind cues are processed by separate pathways and integrated within the fan-shaped body to support goal-directed navigation<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Andrew M. M. Matheson, Aaron J. Lanz, Ashley M. Medina, Al M. Licata, Timothy A. Currier, Mubarak H. Syed &amp; Katherine I. Nagel. <a href=\"https:\/\/www.nature.com\/articles\/s41467-022-32247-7\"><strong>A neural circuit for wind-guided olfactory navigation<\/strong><\/a>. Nat Commun 13, 4613 (2022). https:\/\/doi.org\/10.1038\/s41467-022-32247-7<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Andrew M. M. Matheson, Aaron J. Lanz, Ashley M. Medina, Al M. Licata, Timothy A. Currier, Mubarak H. Syed &amp; Katherine I. Nagel. A neural circuit for wind-guided olfactory navigation. Nat Commun 13, 4613 (2022). https:\/\/doi.org\/10.1038\/s41467-022-32247-7 Abstract &#8220;To navigate towards a food source, animals frequently combine odor cues about source identity with wind direction cues [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,468,346],"tags":[460,1046,466,1047,814],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2667"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2667"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2667\/revisions"}],"predecessor-version":[{"id":2668,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2667\/revisions\/2668"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}