{"id":2675,"date":"2022-08-23T10:38:42","date_gmt":"2022-08-23T00:38:42","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2675"},"modified":"2022-08-23T10:38:42","modified_gmt":"2022-08-23T00:38:42","slug":"how-does-the-brain-process-coordinated-head-direction-representations-in-mouse-anterodorsal-thalamic-nucleus-and-retrosplenial-cortex","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2675","title":{"rendered":"How does the brain process coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex?"},"content":{"rendered":"<p style=\"text-align: justify;\">Marie-Sophie H van der Goes, Jakob Voigts, Jonathan P Newman, Enrique H S Toloza, Norma J Brown, Pranav Murugan, Mark T Harnett. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.08.20.504604v1\"><strong>Coordinated Head Direction Representations in Mouse Anterodorsal Thalamic Nucleus and Retrosplenial Cortex<\/strong><\/a>.\u00a0bioRxiv 2022.08.20.504604; doi: https:\/\/doi.org\/10.1101\/2022.08.20.504604<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">The sense of direction is critical for survival in changing environments and relies on flexibly integrating self-motion signals with external sensory cues.<\/span> <span style=\"color: #ff0000;\">While the anatomical substrates involved in head direction (HD) coding are well known, the mechanisms by which visual information updates HD representations remain poorly understood.<\/span><\/strong> Retrosplenial cortex (RSC) plays a key role in forming coherent representations of space in mammals and it encodes a variety of navigational variables, including HD. Here, we use simultaneous two-area tetrode recording to show that <strong><span style=\"color: #ff0000;\">RSC HD representation is nearly synchronous with that of the anterodorsal nucleus of thalamus (ADn), the obligatory thalamic relay of HD to cortex, during rotation of a prominent visual cue<\/span><\/strong>. Moreover, <strong><span style=\"color: #ff0000;\">coordination of HD representations in the two regions is maintained during darkness<\/span><\/strong>. We further show that anatomical and functional connectivity are consistent with a strong feedforward drive of HD information from ADn to RSC, with surprisingly little reciprocal drive in the corticothalamic direction. Together, <strong><span style=\"color: #ff0000;\">our results provide direct evidence for a concerted global HD reference update across cortex and thalamus, and establish the underlying functional connectivity that supports this coordination<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Marie-Sophie H van der Goes, Jakob Voigts, Jonathan P Newman, Enrique H S Toloza, Norma J Brown, Pranav Murugan, Mark T Harnett. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.08.20.504604v1\"><strong>Coordinated Head Direction Representations in Mouse Anterodorsal Thalamic Nucleus and Retrosplenial Cortex<\/strong><\/a>.\u00a0bioRxiv 2022.08.20.504604; doi: https:\/\/doi.org\/10.1101\/2022.08.20.504604<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Marie-Sophie H van der Goes, Jakob Voigts, Jonathan P Newman, Enrique H S Toloza, Norma J Brown, Pranav Murugan, Mark T Harnett. Coordinated Head Direction Representations in Mouse Anterodorsal Thalamic Nucleus and Retrosplenial Cortex.\u00a0bioRxiv 2022.08.20.504604; doi: https:\/\/doi.org\/10.1101\/2022.08.20.504604 Abstract &#8220;The sense of direction is critical for survival in changing environments and relies on flexibly integrating self-motion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346],"tags":[1053,253,1052],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2675"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2675"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2675\/revisions"}],"predecessor-version":[{"id":2676,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2675\/revisions\/2676"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}