{"id":2680,"date":"2022-09-01T16:51:02","date_gmt":"2022-09-01T06:51:02","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2680"},"modified":"2022-09-01T16:51:02","modified_gmt":"2022-09-01T06:51:02","slug":"how-hippocampal-astrocytes-encode-reward-location","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2680","title":{"rendered":"How hippocampal astrocytes encode reward location?"},"content":{"rendered":"<p style=\"text-align: justify;\">Adi Doron, Alon Rubin, Aviya Benmelech-Chovav, Netai Benaim, Tom Carmi, Ron Refaeli, Nechama Novick, Tirzah Kreisel, Yaniv Ziv &amp; Inbal Goshen. <a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05146-6\"><strong>Hippocampal astrocytes encode reward location<\/strong><\/a>. Nature (2022). https:\/\/doi.org\/10.1038\/s41586-022-05146-6<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;Astrocytic calcium dynamics has been implicated in the encoding of sensory information1,2,3,4,5, and modulation of calcium in astrocytes has been shown to affect behaviour6,7,8,9,10. <strong><span style=\"color: #ff0000;\">However, longitudinal investigation of the real-time calcium activity of astrocytes in the hippocampus of awake mice is lacking<\/span><\/strong>. Here we used two-photon microscopy to chronically image CA1 astrocytes as mice ran in familiar or new virtual environments to obtain water rewards. <strong><span style=\"color: #ff0000;\">We found that astrocytes exhibit persistent ramping activity towards the reward location in a familiar environment, but not in a new one.<\/span><\/strong> Shifting the reward location within a familiar environment also resulted in diminished ramping. <strong><span style=\"color: #ff0000;\">After additional training, as the mice became familiar with the new context or new reward location, the ramping was re-established<\/span><\/strong>. Using linear decoders, we could predict the location of the mouse in a familiar environment from astrocyte activity alone. We could not do the same in a new environment, <strong><span style=\"color: #ff0000;\">suggesting that the spatial modulation of astrocytic activity is experience dependent.<\/span><\/strong> Our results indicate that <strong><span style=\"color: #ff0000;\">astrocytes can encode the expected reward location in spatial contexts, thereby extending their known computational abilities and their role in cognitive functions<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Adi Doron, Alon Rubin, Aviya Benmelech-Chovav, Netai Benaim, Tom Carmi, Ron Refaeli, Nechama Novick, Tirzah Kreisel, Yaniv Ziv &amp; Inbal Goshen. <a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05146-6\"><strong>Hippocampal astrocytes encode reward location<\/strong><\/a>. Nature (2022). https:\/\/doi.org\/10.1038\/s41586-022-05146-6<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Adi Doron, Alon Rubin, Aviya Benmelech-Chovav, Netai Benaim, Tom Carmi, Ron Refaeli, Nechama Novick, Tirzah Kreisel, Yaniv Ziv &amp; Inbal Goshen. Hippocampal astrocytes encode reward location. Nature (2022). https:\/\/doi.org\/10.1038\/s41586-022-05146-6 Abstract &#8220;Astrocytic calcium dynamics has been implicated in the encoding of sensory information1,2,3,4,5, and modulation of calcium in astrocytes has been shown to affect behaviour6,7,8,9,10. However, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346,519],"tags":[1058,258,1059],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2680"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2680"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2680\/revisions"}],"predecessor-version":[{"id":2681,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2680\/revisions\/2681"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}