{"id":2707,"date":"2022-09-28T10:56:11","date_gmt":"2022-09-28T00:56:11","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2707"},"modified":"2022-09-28T10:56:11","modified_gmt":"2022-09-28T00:56:11","slug":"how-hippocampal-cellular-diversity-relates-to-the-different-hippocampal-network-computations-that-support-memory-guided-behavior","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2707","title":{"rendered":"How hippocampal cellular diversity relates to the different hippocampal network computations that support memory-guided behavior?"},"content":{"rendered":"<p style=\"text-align: justify;\">Ryan E Harvey, Heath L Robinson, Can Liu, Azahara Oliva, Antonio Fernandez-Ruiz. <strong><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.09.25.509420v1\">Hippocampo-cortical circuits for selective memory encoding, routing, and replay<\/a><\/strong>.\u00a0bioRxiv 2022.09.25.509420; doi: https:\/\/doi.org\/10.1101\/2022.09.25.509420<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;Traditionally considered a homogeneous cell type, <strong><span style=\"color: #ff0000;\">hippocampal pyramidal cells have been recently shown to be highly diverse<\/span><\/strong>. However, <span style=\"color: #ff0000;\"><strong>how this cellular diversity relates to the different hippocampal network computations that support memory-guided behavior is not yet known<\/strong><\/span>. We discovered that the anatomical identity of pyramidal cells is a major organizing principle of CA1 assembly dynamics, the emergence of memory replay, and cortical projection patterns. Segregated pyramidal cell subpopulations encoded trajectory and choice-specific information or tracked changes in reward configuration respectively, and selectively routed these representations to different cortical targets. Furthermore, <strong><span style=\"color: #ff0000;\">distinct hippocampo-cortical assemblies coordinated the reactivation of complementary memory representations<\/span><\/strong>. These findings <strong><span style=\"color: #ff0000;\">reveal the existence of specialized hippocampo-cortical subcircuits<\/span><\/strong> and provide a cellular mechanism that<strong><span style=\"color: #ff0000;\"> supports the computational flexibility and memory capacities of these structures<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Ryan E Harvey, Heath L Robinson, Can Liu, Azahara Oliva, Antonio Fernandez-Ruiz. <strong><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.09.25.509420v1\">Hippocampo-cortical circuits for selective memory encoding, routing, and replay<\/a><\/strong>.\u00a0bioRxiv 2022.09.25.509420; doi: https:\/\/doi.org\/10.1101\/2022.09.25.509420<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ryan E Harvey, Heath L Robinson, Can Liu, Azahara Oliva, Antonio Fernandez-Ruiz. Hippocampo-cortical circuits for selective memory encoding, routing, and replay.\u00a0bioRxiv 2022.09.25.509420; doi: https:\/\/doi.org\/10.1101\/2022.09.25.509420 Abstract &#8220;Traditionally considered a homogeneous cell type, hippocampal pyramidal cells have been recently shown to be highly diverse. However, how this cellular diversity relates to the different hippocampal network computations that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96],"tags":[718,1086,148,994,1087],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2707"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2707"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2707\/revisions"}],"predecessor-version":[{"id":2708,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2707\/revisions\/2708"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}