{"id":2716,"date":"2022-10-05T13:36:48","date_gmt":"2022-10-05T03:36:48","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2716"},"modified":"2022-10-05T13:36:48","modified_gmt":"2022-10-05T03:36:48","slug":"how-hippocampal-neurons-with-object-anchored-firing-fields-contribute-to-homing-based-on-path-integration-in-navigation","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2716","title":{"rendered":"How hippocampal neurons with object-anchored firing fields contribute to homing based on path integration in navigation?"},"content":{"rendered":"<p style=\"text-align: justify;\">Maryam Najafian Jazi, Adrian Tymorek, Ting Yung Yen, Felix Jose Kavarayil, Moritz Stingl, Sherman Richard Chau, Benay Baskurt, Celia Garcia Vilela, Kevin Allen. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.09.30.510268v1\"><strong>Hippocampal firing fields anchored to a moving object predict homing direction during path-integration-based behavior.<\/strong><\/a>\u00a0bioRxiv 2022.09.30.510268; doi: https:\/\/doi.org\/10.1101\/2022.09.30.510268<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Homing based on path integration (H-PI) is a form of navigation in which an animal uses self-motion cues to keep track of its position and return to a starting point.<\/span><\/strong> Despite evidence for a role of the hippocampus in H-PI, the firing patterns of hippocampal neurons associated with homing performance are unknown. <strong><span style=\"color: #ff0000;\">Here we developed a behavioral task for mice to characterize spatially selective cells during H-PI.<\/span><\/strong> The task required a mouse to find a variably placed lever on an arena before returning to its home base. <strong><span style=\"color: #ff0000;\">H-PI was assessed in complete darkness.<\/span> <span style=\"color: #ff0000;\">Recordings from CA1 pyramidal neurons in mice showed that several firing fields were anchored to the lever position<\/span><\/strong>. The spatial stability of lever-anchored fields was reduced during trials with lower homing accuracy, and <strong><span style=\"color: #ff0000;\">the activity of a subset of lever-anchored firing fields predicted homing direction.<\/span><\/strong> These results demonstrate how neurons with object-anchored firing fields contribute to navigation.&#8221;<\/p>\n<p style=\"text-align: justify;\">Maryam Najafian Jazi, Adrian Tymorek, Ting Yung Yen, Felix Jose Kavarayil, Moritz Stingl, Sherman Richard Chau, Benay Baskurt, Celia Garcia Vilela, Kevin Allen. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.09.30.510268v1\"><strong>Hippocampal firing fields anchored to a moving object predict homing direction during path-integration-based behavior.<\/strong><\/a>\u00a0bioRxiv 2022.09.30.510268; doi: https:\/\/doi.org\/10.1101\/2022.09.30.510268<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Maryam Najafian Jazi, Adrian Tymorek, Ting Yung Yen, Felix Jose Kavarayil, Moritz Stingl, Sherman Richard Chau, Benay Baskurt, Celia Garcia Vilela, Kevin Allen. Hippocampal firing fields anchored to a moving object predict homing direction during path-integration-based behavior.\u00a0bioRxiv 2022.09.30.510268; doi: https:\/\/doi.org\/10.1101\/2022.09.30.510268 Abstract &#8220;Homing based on path integration (H-PI) is a form of navigation in which an [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346,849],"tags":[1097,1096,1095,292],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2716"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2716"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2716\/revisions"}],"predecessor-version":[{"id":2717,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2716\/revisions\/2717"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}