{"id":2748,"date":"2022-12-07T16:42:13","date_gmt":"2022-12-07T06:42:13","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2748"},"modified":"2022-12-07T16:42:13","modified_gmt":"2022-12-07T06:42:13","slug":"how-dopamine-promotes-head-direction-plasticity-during-orienting-movements","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2748","title":{"rendered":"How dopamine promotes head direction plasticity during orienting movements?"},"content":{"rendered":"<p style=\"text-align: justify;\">Yvette E. Fisher, Michael Marquis, Isabel D\u2019Alessandro&amp; Rachel I. Wilson. <a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05485-4\"><strong>Dopamine promotes head direction plasticity during orienting movements<\/strong><\/a>. Nature (2022). https:\/\/doi.org\/10.1038\/s41586-022-05485-4<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">In neural networks that store information in their connection weights, there is a tradeoff between sensitivity and stability<\/span><\/strong>1,2. <strong><span style=\"color: #ff0000;\">Connections must be plastic to incorporate new information, but if they are too plastic, stored information can be corrupted<\/span><\/strong>. A potential solution is to allow plasticity only during epochs when task-specific information is rich, on the basis of a \u2018when-to-learn\u2019 signal3. <strong><span style=\"color: #ff0000;\">We reasoned that dopamine provides a when-to-learn signal that allows the brain\u2019s spatial maps to update when new spatial information is available\u2014that is, when an animal is moving<\/span><\/strong>. Here we show that the dopamine neurons innervating the Drosophila head direction network are specifically active when the fly turns to change its head direction. Moreover, their activity scales with moment-to-moment fluctuations in rotational speed. Pairing dopamine release with a visual cue persistently strengthens the cue\u2019s influence on head direction cells. Conversely, inhibiting these dopamine neurons decreases the influence of the cue. <strong><span style=\"color: #ff0000;\">This mechanism should accelerate learning during moments when orienting movements are providing a rich stream of head direction information, allowing learning rates to be low at other times to protect stored information<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">Our results show how spatial learning in the brain can be compressed into discrete epochs in which high learning rates are matched to high rates of information intake<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Yvette E. Fisher, Michael Marquis, Isabel D\u2019Alessandro&amp; Rachel I. Wilson. <a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05485-4\"><strong>Dopamine promotes head direction plasticity during orienting movements<\/strong><\/a>. Nature (2022). https:\/\/doi.org\/10.1038\/s41586-022-05485-4<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yvette E. Fisher, Michael Marquis, Isabel D\u2019Alessandro&amp; Rachel I. Wilson. Dopamine promotes head direction plasticity during orienting movements. Nature (2022). https:\/\/doi.org\/10.1038\/s41586-022-05485-4 Abstract &#8220;In neural networks that store information in their connection weights, there is a tradeoff between sensitivity and stability1,2. Connections must be plastic to incorporate new information, but if they are too plastic, stored [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346,519],"tags":[1128,1129,1002],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2748"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2748"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2748\/revisions"}],"predecessor-version":[{"id":2749,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2748\/revisions\/2749"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}