{"id":2758,"date":"2022-12-28T11:38:00","date_gmt":"2022-12-28T01:38:00","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2758"},"modified":"2022-12-28T11:38:00","modified_gmt":"2022-12-28T01:38:00","slug":"whats-the-role-of-the-lateral-orbitofrontal-cortex-in-creating-cognitive-maps","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2758","title":{"rendered":"What&#8217;s the role of the lateral orbitofrontal cortex in creating cognitive maps?"},"content":{"rendered":"<p style=\"text-align: justify;\">Kau\u00ea Machado Costa, Robert Scholz, Kevin Lloyd, Perla Moreno-Castilla, Matthew P. H. Gardner, Peter Dayan &amp; Geoffrey Schoenbaum. <a href=\"https:\/\/www.nature.com\/articles\/s41593-022-01216-0\"><strong>The role of the lateral orbitofrontal cortex in creating cognitive maps<\/strong><\/a>. Nat Neurosci (2022). https:\/\/doi.org\/10.1038\/s41593-022-01216-0<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">We use mental models of the world\u2014cognitive maps\u2014to guide behavior<\/span><\/strong>. The lateral orbitofrontal cortex (lOFC) is typically thought to support behavior by deploying these maps to simulate outcomes, but recent evidence suggests that it may instead support behavior by underlying map creation. We tested between these two alternatives using outcome-specific devaluation and a high-potency chemogenetic approach. <strong><span style=\"color: #ff0000;\">Selectively inactivating lOFC principal neurons when male rats learned distinct cue\u2013outcome associations, but before outcome devaluation, disrupted subsequent inference, confirming a role for the lOFC in creating new maps<\/span><\/strong>. However, lOFC inactivation surprisingly led to generalized devaluation, a result that is inconsistent with a complete mapping failure. <strong><span style=\"color: #ff0000;\">Using a reinforcement learning framework, we show that this effect is best explained by a circumscribed deficit in credit assignment precision during map construction, suggesting that the lOFC has a selective role in defining the specificity of associations that comprise cognitive maps<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Kau\u00ea Machado Costa, Robert Scholz, Kevin Lloyd, Perla Moreno-Castilla, Matthew P. H. Gardner, Peter Dayan &amp; Geoffrey Schoenbaum. <a href=\"https:\/\/www.nature.com\/articles\/s41593-022-01216-0\"><strong>The role of the lateral orbitofrontal cortex in creating cognitive maps<\/strong><\/a>. Nat Neurosci (2022). https:\/\/doi.org\/10.1038\/s41593-022-01216-0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kau\u00ea Machado Costa, Robert Scholz, Kevin Lloyd, Perla Moreno-Castilla, Matthew P. H. Gardner, Peter Dayan &amp; Geoffrey Schoenbaum. The role of the lateral orbitofrontal cortex in creating cognitive maps. Nat Neurosci (2022). https:\/\/doi.org\/10.1038\/s41593-022-01216-0 Abstract &#8220;We use mental models of the world\u2014cognitive maps\u2014to guide behavior. The lateral orbitofrontal cortex (lOFC) is typically thought to support behavior [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[1140,1139],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2758"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2758"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2758\/revisions"}],"predecessor-version":[{"id":2759,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2758\/revisions\/2759"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2758"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}