{"id":2768,"date":"2023-01-05T11:20:17","date_gmt":"2023-01-05T01:20:17","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2768"},"modified":"2023-01-05T11:20:17","modified_gmt":"2023-01-05T01:20:17","slug":"how-the-hippocampus-incorporates-new-contextual-information-into-a-previously-formed-and-stabilized-spatial-representation","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2768","title":{"rendered":"How the hippocampus incorporates new contextual information into a previously formed and stabilized spatial representation?"},"content":{"rendered":"<p style=\"text-align: justify;\">Jake Ormond, Simon A. Serka, Joshua P. Johansen. <a href=\"https:\/\/www.jneurosci.org\/content\/early\/2023\/01\/03\/JNEUROSCI.1450-22.2022\"><strong>Enhanced reactivation of remapping place cells during aversive learning<\/strong><\/a>. Journal of Neuroscience 3 January 2023, JN-RM-1450-22; DOI: 10.1523\/JNEUROSCI.1450-22.2022<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Study of the hippocampal place cell system has greatly enhanced our understanding of memory encoding for distinct places<\/span><\/strong>, but <strong><span style=\"color: #ff0000;\">how episodic memories for distinct experiences occurring within familiar environments are encoded is less clear<\/span><\/strong>. We developed a spatial decision-making task in which male rats learned to navigate a multi-arm maze to a goal location for food reward while avoiding maze arms in which aversive stimuli were delivered. <strong><span style=\"color: #ff0000;\">Task learning induced partial remapping in CA1 place cells, allowing us to identify both remapping and stable cell populations<\/span><\/strong>. Remapping cells were recruited into sharp wave ripples (SWRs) and associated replay events to a greater extent than stable cells, despite having similar firing rates during navigation of the maze. <strong><span style=\"color: #ff0000;\">Our results suggest that recruitment into replay events may be a mechanism to incorporate new contextual information into a previously formed and stabilized spatial representation<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">\nSIGNIFICANCE STATEMENT:<\/p>\n<p style=\"text-align: justify;\">\n&#8220;Hippocampal place cells provide a map of space which animals use to navigate. <strong><span style=\"color: #ff0000;\">This map can change to reflect changes in the physical properties of the environment in which the animal finds itself, and also in response to non-physical contextual changes, such as changes in valence of specific locations within that environment<\/span><\/strong>. We show here that cells which change their spatial tuning after a change in context are preferentially recruited into SWR-associated replay events compared to stable non-remapping cells. Thus, our data lend strong support to<strong><span style=\"color: #ff0000;\"> the hypothesis that replay is a mechanism for the storage of new spatial maps<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Jake Ormond, Simon A. Serka, Joshua P. Johansen. <a href=\"https:\/\/www.jneurosci.org\/content\/early\/2023\/01\/03\/JNEUROSCI.1450-22.2022\"><strong>Enhanced reactivation of remapping place cells during aversive learning<\/strong><\/a>. Journal of Neuroscience 3 January 2023, JN-RM-1450-22; DOI: 10.1523\/JNEUROSCI.1450-22.2022<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jake Ormond, Simon A. Serka, Joshua P. Johansen. Enhanced reactivation of remapping place cells during aversive learning. Journal of Neuroscience 3 January 2023, JN-RM-1450-22; DOI: 10.1523\/JNEUROSCI.1450-22.2022 Abstract &#8220;Study of the hippocampal place cell system has greatly enhanced our understanding of memory encoding for distinct places, but how episodic memories for distinct experiences occurring within familiar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346,519],"tags":[1158,365,104,830,994,1157],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2768"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2768"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2768\/revisions"}],"predecessor-version":[{"id":2769,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2768\/revisions\/2769"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2768"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2768"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2768"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}