{"id":2776,"date":"2023-01-30T12:38:08","date_gmt":"2023-01-30T02:38:08","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2776"},"modified":"2023-01-30T12:38:08","modified_gmt":"2023-01-30T02:38:08","slug":"how-navigation-and-memory-processes-interact-in-humans","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2776","title":{"rendered":"How navigation and memory processes interact in humans?"},"content":{"rendered":"<p style=\"text-align: justify;\">Thomas Schreiner, Benjamin J. Griffiths, Merve Kutlu, Christian Vollmar, Elisabeth Kaufmann, Stefanie Quach, Jan Remi, Soheyl Noachtar, Tobias Staudigl. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.01.27.525854v1\"><strong>Memory reactivation of real-world spatial orientation revealed by human electrophysiology<\/strong><\/a>.\u00a0bioRxiv 2023.01.27.525854; doi: https:\/\/doi.org\/10.1101\/2023.01.27.525854<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<span style=\"color: #ff0000;\"><strong>Spatial navigation and memory are thought to rely on common neuronal mechanisms, enabling us to travel in physical and mental space<\/strong><\/span>. Seminal findings in animal models support this assumption. <strong><span style=\"color: #ff0000;\">However, how navigation and memory processes interact in humans is not well understood<\/span><\/strong>. Here <strong><span style=\"color: #ff0000;\">we tested whether real-world head orientations act as spatial context for memories by investigating their reactivation during wake and sleep<\/span><\/strong>. We recorded intracranial electrophysiology in epilepsy patients and scalp EEG in healthy participants while they retrieved real-world head orientations as well as while targeted memory reactivation (TMR) was applied during subsequent non-rapid eye movement (NREM) sleep. <strong><span style=\"color: #ff0000;\">We show that head orientation-related signals are reactivated during successful memory retrieval, suggesting that they provide specific memories with spatial information<\/span><\/strong>. Moreover, we found that TMR triggered reactivation of prior learned head orientations during sleep. Sleep related memory reactivation was paralleled and predicted by increased power in the SO-spindle range while being accompanied by elevated levels of ripples recorded intracranially from the medial temporal lobe. <strong><span style=\"color: #ff0000;\">In conclusion, our results suggest that core features of spatial navigation add contextual spatial information to newly formed memory traces<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Thomas Schreiner, Benjamin J. Griffiths, Merve Kutlu, Christian Vollmar, Elisabeth Kaufmann, Stefanie Quach, Jan Remi, Soheyl Noachtar, Tobias Staudigl. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.01.27.525854v1\"><strong>Memory reactivation of real-world spatial orientation revealed by human electrophysiology<\/strong><\/a>.\u00a0bioRxiv 2023.01.27.525854; doi: https:\/\/doi.org\/10.1101\/2023.01.27.525854<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thomas Schreiner, Benjamin J. Griffiths, Merve Kutlu, Christian Vollmar, Elisabeth Kaufmann, Stefanie Quach, Jan Remi, Soheyl Noachtar, Tobias Staudigl. Memory reactivation of real-world spatial orientation revealed by human electrophysiology.\u00a0bioRxiv 2023.01.27.525854; doi: https:\/\/doi.org\/10.1101\/2023.01.27.525854 Abstract &#8220;Spatial navigation and memory are thought to rely on common neuronal mechanisms, enabling us to travel in physical and mental space. Seminal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346,519],"tags":[1165,1166,835,358,211],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2776"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2776"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2776\/revisions"}],"predecessor-version":[{"id":2777,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2776\/revisions\/2777"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}