{"id":2786,"date":"2023-02-03T11:18:31","date_gmt":"2023-02-03T01:18:31","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2786"},"modified":"2023-02-03T11:18:31","modified_gmt":"2023-02-03T01:18:31","slug":"how-episodic-memories-are-stored-within-brains","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2786","title":{"rendered":"How episodic memories are stored within brains?"},"content":{"rendered":"<p style=\"text-align: justify;\">Sachin P Vaidya, Raymond A Chitwood, Jeffrey C Magee. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.02.01.526663v1\"><strong>The formation of an expanding memory representation in the hippocampus<\/strong><\/a>. bioRxiv 2023.02.01.526663; doi: https:\/\/doi.org\/10.1101\/2023.02.01.526663<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<span style=\"color: #ff0000;\"><strong>How episodic memories are stored within brains is poorly understood<\/strong><\/span>. While <strong><span style=\"color: #ff0000;\">certain memory-retaining neurons<\/span><\/strong> have been potentially identified, <strong><span style=\"color: #ff0000;\">it is unclear if they retain learned information<\/span><\/strong>. Further, there is considerable evidence that neuronal activity is unstable and may require additional mechanisms to support robust memory. To examine these issues, we recorded the activity of a hippocampal CA1 neuronal population for 7 days as mice learned cued reward locations. <strong><span style=\"color: #ff0000;\">These data and modelling results suggest that two place cell (PC) pools, distinguished by place field (PF) stability, are formed each day<\/span><\/strong> (transient: ~1.5 days; sustained: ~2 weeks)8. Notably, t<strong><span style=\"color: #ff0000;\">he proportions of these pools changed across the week as unstable transient PCs were progressively replaced by sustained PCs, markedly enhancing the stability of the total representation<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">This growing stable representation contained behaviorally relevant information and sustained PCs became active immediately at the start of each session<\/span><\/strong>. Finally, the initial formation of sustained PCs was associated with a higher rate and efficacy of behavioral timescale synaptic plasticity (BTSP) and these PCs showed elevated and more reliable activity. It, therefore, <strong><span style=\"color: #ff0000;\">appears that BTSP stabilizes particularly informative PCs, incorporating them into an expanding and readily retrievable representation that displays hallmarks of a long-lasting memory<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Sachin P Vaidya, Raymond A Chitwood, Jeffrey C Magee. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.02.01.526663v1\"><strong>The formation of an expanding memory representation in the hippocampus<\/strong><\/a>. bioRxiv 2023.02.01.526663; doi: https:\/\/doi.org\/10.1101\/2023.02.01.526663<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sachin P Vaidya, Raymond A Chitwood, Jeffrey C Magee. The formation of an expanding memory representation in the hippocampus. bioRxiv 2023.02.01.526663; doi: https:\/\/doi.org\/10.1101\/2023.02.01.526663 Abstract &#8220;How episodic memories are stored within brains is poorly understood. While certain memory-retaining neurons have been potentially identified, it is unclear if they retain learned information. Further, there is considerable evidence [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,636,519],"tags":[1177,349,104,243],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2786"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2786"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2786\/revisions"}],"predecessor-version":[{"id":2787,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2786\/revisions\/2787"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2786"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2786"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2786"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}