{"id":2795,"date":"2023-02-17T10:50:38","date_gmt":"2023-02-17T00:50:38","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2795"},"modified":"2023-02-17T10:50:38","modified_gmt":"2023-02-17T00:50:38","slug":"how-spinal-circuits-implement-the-locomotor-command","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2795","title":{"rendered":"How spinal circuits implement the locomotor command?"},"content":{"rendered":"<p style=\"text-align: justify;\">Hsu, LJ., Bertho, M. &amp; Kiehn, O. <a href=\"https:\/\/www.nature.com\/articles\/s41467-023-36587-w\"><strong>Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks<\/strong><\/a>. Nat Commun 14, 873 (2023). https:\/\/doi.org\/10.1038\/s41467-023-36587-w<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;Locomotion empowers animals to move. Locomotor-initiating signals from the brain are funneled through descending neurons in the brainstem that act directly on spinal locomotor circuits. <strong><span style=\"color: #ff0000;\">Little is known in mammals about which spinal circuits are targeted by the command and how this command is transformed into rhythmicity in the cord<\/span><\/strong>. Here <strong><span style=\"color: #ff0000;\">we address these questions leveraging a mouse brainstem-spinal cord preparation from either sex that allows locating the locomotor command neurons with simultaneous Ca2+ imaging of spinal neurons<\/span><\/strong>. We show that a restricted brainstem area \u2013 encompassing the lateral paragigantocellular nucleus (LPGi) and caudal ventrolateral reticular nucleus (CVL) \u2013 contains glutamatergic neurons which directly initiate locomotion. <strong><span style=\"color: #ff0000;\">Ca2+ imaging captures the direct LPGi\/CVL locomotor initiating command in the spinal cord and visualizes spinal glutamatergic modules that execute the descending command and its transformation into rhythmic locomotor activity<\/span><\/strong>. Inhibitory spinal networks are recruited in a distinctly different pattern. Our study uncovers the principal logic of how spinal circuits implement the locomotor command using a distinct modular organization.&#8221;<\/p>\n<p style=\"text-align: justify;\">Hsu, LJ., Bertho, M. &amp; Kiehn, O. <a href=\"https:\/\/www.nature.com\/articles\/s41467-023-36587-w\"><strong>Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks<\/strong><\/a>. Nat Commun 14, 873 (2023). https:\/\/doi.org\/10.1038\/s41467-023-36587-w<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hsu, LJ., Bertho, M. &amp; Kiehn, O. Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks. Nat Commun 14, 873 (2023). https:\/\/doi.org\/10.1038\/s41467-023-36587-w Abstract &#8220;Locomotion empowers animals to move. Locomotor-initiating signals from the brain are funneled through descending neurons in the brainstem that act directly on spinal locomotor circuits. Little is known in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1184,1185,1186],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2795"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2795"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2795\/revisions"}],"predecessor-version":[{"id":2796,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2795\/revisions\/2796"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}