{"id":2801,"date":"2023-02-21T22:51:28","date_gmt":"2023-02-21T12:51:28","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2801"},"modified":"2023-02-21T22:51:28","modified_gmt":"2023-02-21T12:51:28","slug":"how-the-brain-avoid-systematic-erasing-of-previously-encoded-memories","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2801","title":{"rendered":"How the brain avoid systematic erasing of previously encoded memories?"},"content":{"rendered":"<p style=\"text-align: justify;\">Irene Navarro-Lobato, Adrian Aleman-Zapata, Anumita Samanta, Milan Bogers, Shekhar Narayanan, Abdelrahman Rayan, Alejandra Alonso, Jacqueline van der Meij, Mehdi Khamassi, Zafar Khan, Lisa Genzel. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.11.21.517356v1\"><strong>Learning Fast and Slow: Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions<\/strong><\/a>.\u00a0bioRxiv 2022.11.21.517356; doi: https:\/\/doi.org\/10.1101\/2022.11.21.517356<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Our brain is continuously challenged by daily experiences. Thus, how to avoid systematic erasing of previously encoded memories?<\/span><\/strong> While it has been proposed that <strong><span style=\"color: #ff0000;\">a dual-learning system with \u201cslow\u201d learning in the cortex and \u201cfast\u201d learning in the hippocampus could protect previous knowledge from interference, this has never been observed in the living organism<\/span><\/strong>. Here, we report that increasing plasticity via the viral-induced overexpression of RGS14414 in the prelimbic cortex leads to better one-trial memory, but that this comes at the price of increased interference in semantic-like memory. Indeed, electrophysiological recordings showed that this manipulation also resulted in shorter NonREM-sleep bouts, smaller delta-waves and decreased neuronal firing rates. In contrast, <strong><span style=\"color: #ff0000;\">hippocampal-cortical interactions in form of theta coherence during wake and REM-sleep as well as oscillatory coupling during NonREM-sleep were enhanced<\/span><\/strong>. Thus, we provide the first experimental evidence for the long-standing and unproven fundamental idea that <strong><span style=\"color: #ff0000;\">high thresholds for plasticity in the cortex protects preexisting memories and modulating these thresholds affects both memory encoding and consolidation mechanisms<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Irene Navarro-Lobato, Adrian Aleman-Zapata, Anumita Samanta, Milan Bogers, Shekhar Narayanan, Abdelrahman Rayan, Alejandra Alonso, Jacqueline van der Meij, Mehdi Khamassi, Zafar Khan, Lisa Genzel. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.11.21.517356v1\"><strong>Learning Fast and Slow: Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions<\/strong><\/a>.\u00a0bioRxiv 2022.11.21.517356; doi: https:\/\/doi.org\/10.1101\/2022.11.21.517356<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Irene Navarro-Lobato, Adrian Aleman-Zapata, Anumita Samanta, Milan Bogers, Shekhar Narayanan, Abdelrahman Rayan, Alejandra Alonso, Jacqueline van der Meij, Mehdi Khamassi, Zafar Khan, Lisa Genzel. Learning Fast and Slow: Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions.\u00a0bioRxiv 2022.11.21.517356; doi: https:\/\/doi.org\/10.1101\/2022.11.21.517356 Summary &#8220;Our brain is continuously challenged by daily experiences. Thus, how to avoid [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,636,519],"tags":[1192,1088,704,1193],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2801"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2801"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2801\/revisions"}],"predecessor-version":[{"id":2802,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2801\/revisions\/2802"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}