{"id":2824,"date":"2023-03-11T10:37:23","date_gmt":"2023-03-11T00:37:23","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2824"},"modified":"2023-03-11T10:37:23","modified_gmt":"2023-03-11T00:37:23","slug":"how-the-hippocampus-accumbens-code-guides-goal-directed-appetitive-behavior","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2824","title":{"rendered":"How the hippocampus-accumbens code guides goal-directed appetitive behavior?"},"content":{"rendered":"<p style=\"text-align: justify;\">Oliver Barnstedt, Petra Mocellin, Stefan Remy. <strong><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.03.09.531869v1\">A hippocampus-accumbens code guides goal-directed appetitive behavior<\/a><\/strong>. bioRxiv 2023.03.09.531869; doi: https:\/\/doi.org\/10.1101\/2023.03.09.531869<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<span style=\"color: #ff0000;\"><strong>Neurons in dorsal hippocampus (dHPC) encode a rich repertoire of task-relevant environmental features<\/strong><\/span>, while downstream regions such as the nucleus accumbens (NAc) translate this information into task-adaptive behaviors. <strong><span style=\"color: #ff0000;\">Yet, the contents of this information stream and their acute role in behavior remain largely unknown<\/span><\/strong>. Here, we used in vivo dual-color two-photon imaging to simultaneously record from both large numbers of <strong><span style=\"color: #ff0000;\">hippocampal neurons<\/span><\/strong> and <strong><span style=\"color: #ff0000;\">an identified subpopulation of NAc-projecting neurons<\/span><\/strong> <strong><span style=\"color: #ff0000;\">during goal-directed navigation towards a hidden reward zone<\/span><\/strong>. We found that <strong><span style=\"color: #ff0000;\">NAc-projecting neurons contain enriched spatial information<\/span><\/strong> and<strong><span style=\"color: #ff0000;\"> enhanced representations of non-spatial task-relevant behaviors such as deceleration and appetitive licking<\/span><\/strong>, both of which could be elicited by optogenetic activation of dHPC terminals in NAc. A generalized linear model revealed enhanced conjunctive coding in NAc-projecting dHPC neurons, improving the identification of the reward zone. <strong><span style=\"color: #ff0000;\">We propose that dHPC routes specific reward-related spatial and behavioral state information to guide NAc action selection<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Oliver Barnstedt, Petra Mocellin, Stefan Remy. <strong><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.03.09.531869v1\">A hippocampus-accumbens code guides goal-directed appetitive behavior<\/a><\/strong>. bioRxiv 2023.03.09.531869; doi: https:\/\/doi.org\/10.1101\/2023.03.09.531869<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oliver Barnstedt, Petra Mocellin, Stefan Remy. A hippocampus-accumbens code guides goal-directed appetitive behavior. bioRxiv 2023.03.09.531869; doi: https:\/\/doi.org\/10.1101\/2023.03.09.531869 Abstract &#8220;Neurons in dorsal hippocampus (dHPC) encode a rich repertoire of task-relevant environmental features, while downstream regions such as the nucleus accumbens (NAc) translate this information into task-adaptive behaviors. Yet, the contents of this information stream and their [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[1214,1188,1213],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2824"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2824"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2824\/revisions"}],"predecessor-version":[{"id":2825,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2824\/revisions\/2825"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2824"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2824"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2824"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}