{"id":2826,"date":"2023-03-12T10:24:04","date_gmt":"2023-03-12T00:24:04","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2826"},"modified":"2023-03-12T10:24:04","modified_gmt":"2023-03-12T00:24:04","slug":"how-distinct-hippocampal-prefrontal-neural-assemblies-coordinate-memory-encoding-maintenance-and-recall","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2826","title":{"rendered":"How distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall?"},"content":{"rendered":"<p style=\"text-align: justify;\">Aleksander P.F. Domanski, Michal T. Kucewicz, Eleonora Russo, Mark D. Tricklebank,\u00a0Emma S.J. Robinson,\u00a0Daniel Durstewitz,\u00a0Matt W. Jones. <a href=\"https:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(23)00169-0#secsectitle0015\"><strong>Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall<\/strong><\/a>. Current Biology, 2023.<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Short-term memory enables incorporation of recent experience into subsequent decision-making<\/span><\/strong>. This processing recruits both the prefrontal cortex and hippocampus, where neurons encode task cues, rules, and outcomes. <strong><span style=\"color: #ff0000;\">However, precisely which information is carried when, and by which neurons, remains unclear<\/span><\/strong>. Using population decoding of activity in rat medial prefrontal cortex (mPFC) and dorsal hippocampal CA1, <strong><span style=\"color: #ff0000;\">we confirm that mPFC populations lead in maintaining sample information across delays of an operant non-match to sample task<\/span><\/strong>, despite individual neurons firing only transiently. During sample encoding, distinct mPFC subpopulations joined distributed CA1-mPFC cell assemblies hallmarked by 4\u20135 Hz rhythmic modulation; CA1-mPFC assemblies re-emerged during choice episodes but were not 4\u20135 Hz modulated. Delay-dependent errors arose when attenuated rhythmic assembly activity heralded collapse of sustained mPFC encoding. <strong><span style=\"color: #ff0000;\">Our results map component processes of memory-guided decisions onto heterogeneous CA1-mPFC subpopulations and the dynamics of physiologically distinct, distributed cell assemblies<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Aleksander P.F. Domanski, Michal T. Kucewicz, Eleonora Russo, Mark D. Tricklebank,\u00a0Emma S.J. Robinson,\u00a0Daniel Durstewitz,\u00a0Matt W. Jones. <a href=\"https:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(23)00169-0#secsectitle0015\"><strong>Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall<\/strong><\/a>. Current Biology, 2023.<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aleksander P.F. Domanski, Michal T. Kucewicz, Eleonora Russo, Mark D. Tricklebank,\u00a0Emma S.J. Robinson,\u00a0Daniel Durstewitz,\u00a0Matt W. Jones. Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall. Current Biology, 2023. Summary &#8220;Short-term memory enables incorporation of recent experience into subsequent decision-making. This processing recruits both the prefrontal cortex and hippocampus, where neurons encode task cues, rules, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346,519],"tags":[1215,1217,1218,807,1216],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2826"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2826"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2826\/revisions"}],"predecessor-version":[{"id":2827,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2826\/revisions\/2827"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2826"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2826"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}