{"id":2832,"date":"2023-03-14T19:43:07","date_gmt":"2023-03-14T09:43:07","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2832"},"modified":"2023-03-14T19:43:07","modified_gmt":"2023-03-14T09:43:07","slug":"how-to-convert-an-allocentric-goal-into-an-egocentric-steering-signal","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2832","title":{"rendered":"How to convert an allocentric goal into an egocentric steering signal?"},"content":{"rendered":"<p style=\"text-align: justify;\">Peter Mussells Pires, L.F. Abbott, Gaby Maimon. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.11.10.516026v1.abstract\"><strong>Converting an allocentric goal into an egocentric steering signal<\/strong><\/a>. bioRxiv 2022.11.10.516026; doi: https:\/\/doi.org\/10.1101\/2022.11.10.516026<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Neuronal signals relevant for spatial navigation have been described in many species1\u201312, however, a circuit-level understanding of how such signals interact to guide behaviour is lacking<\/span><\/strong>. Here <strong><span style=\"color: #ff0000;\">we characterize a neuronal circuit in the Drosophila central complex that compares internally generated estimates of the fly\u2019s heading and goal angles\u2013\u2013both encoded in world-centred, or allocentric, coordinates\u2013\u2013to generate a body-centred, or egocentric, steering signal<\/span><\/strong>. Past work has argued that the activity of EPG cells, or \u201ccompass neurons\u201d2, represents the fly\u2019s moment-to-moment angular orientation, or heading angle, during navigation13. An animal\u2019s moment-to-moment heading angle, however, is not always aligned with its goal angle, i.e., the allocentric direction in which it wishes to progress forward. We describe a second set of neurons in the Drosophila brain, FC2 cells14, with activity that correlates with the fly\u2019s goal angle. Furthermore, focal optogenetic activation of FC2 neurons induces flies to orient along experimenter-defined directions as they walk forward. EPG and FC2 cells connect monosynaptically to a third neuronal class, PFL3 cells14,15. <strong><span style=\"color: #ff0000;\">We found that individual PFL3 cells show conjunctive, spike-rate tuning to both heading and goal angles during goal-directed navigation<\/span><\/strong>. Informed by the anatomy and physiology of these three cell classes, <strong><span style=\"color: #ff0000;\">we develop a formal model for how this circuit can compare allocentric heading- and goal-angles to build an egocentric steering signal in the PFL3 output terminals<\/span><\/strong>. Quantitative analyses and optogenetic manipulations of PFL3 activity support the model. <strong><span style=\"color: #ff0000;\">The biological circuit described here reveals how two, population-level, allocentric signals are compared in the brain to produce an egocentric output signal appropriate for the motor system<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Peter Mussells Pires, L.F. Abbott, Gaby Maimon. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.11.10.516026v1.abstract\"><strong>Converting an allocentric goal into an egocentric steering signal<\/strong><\/a>. bioRxiv 2022.11.10.516026; doi: https:\/\/doi.org\/10.1101\/2022.11.10.516026<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Peter Mussells Pires, L.F. Abbott, Gaby Maimon. Converting an allocentric goal into an egocentric steering signal. bioRxiv 2022.11.10.516026; doi: https:\/\/doi.org\/10.1101\/2022.11.10.516026 Abstract &#8220;Neuronal signals relevant for spatial navigation have been described in many species1\u201312, however, a circuit-level understanding of how such signals interact to guide behaviour is lacking. Here we characterize a neuronal circuit in the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[960,346,532],"tags":[1222,1224,1223],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2832"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2832"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2832\/revisions"}],"predecessor-version":[{"id":2833,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2832\/revisions\/2833"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2832"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2832"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}