{"id":2839,"date":"2023-03-17T13:37:08","date_gmt":"2023-03-17T03:37:08","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2839"},"modified":"2023-03-17T13:37:08","modified_gmt":"2023-03-17T03:37:08","slug":"how-cognitive-maps-are-transformed-across-hippocampal-prefrontal-circuits-to-support-abstraction-and-generalization","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2839","title":{"rendered":"How cognitive maps are transformed across hippocampal-prefrontal circuits to support abstraction and generalization?"},"content":{"rendered":"<p style=\"text-align: justify;\">Wenbo Tang, Justin D. Shin, Shantanu P. Jadhav. <strong><a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2023.112246\">Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits<\/a><\/strong>.\u00a0Cell Reports 42, 112246,\u00a0March 28, 2023.\u00a0<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n&#8220;<span style=\"color: #ff0000;\"><strong>The ability to abstract information to guide decisions during navigation across changing environments is essential for adaptation and requires the integrity of the hippocampal-prefrontal circuitry<\/strong><\/span>. The hippocampus encodes navigational information in a cognitive map, but <strong><span style=\"color: #ff0000;\">it remains unclear how cognitive maps are transformed across hippocampal-prefrontal circuits to support abstraction and generalization<\/span><\/strong>. Here, <strong><span style=\"color: #ff0000;\">we simultaneously record hippocampal-prefrontal ensembles as rats generalize navigational rules across distinct environments<\/span><\/strong>. We find that, whereas hippocampal representational maps maintain specificity of separate environments, prefrontal maps generalize across environments. Furthermore, while both maps are structured within a neural manifold of population activity, they have distinct representational geometries. <strong><span style=\"color: #ff0000;\">Prefrontal geometry enables abstraction of rule-informative variables<\/span><\/strong>, a representational format that generalizes to novel conditions of existing variable classes. <strong><span style=\"color: #ff0000;\">Hippocampal geometry lacks such abstraction<\/span><\/strong>. Together, <strong><span style=\"color: #ff0000;\">these findings elucidate how cognitive maps are structured into distinct geometric representations to support abstraction and generalization while maintaining memory specificity<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Wenbo Tang, Justin D. Shin, Shantanu P. Jadhav. <strong><a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2023.112246\">Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits<\/a><\/strong>.\u00a0Cell Reports 42, 112246,\u00a0March 28, 2023.\u00a0<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wenbo Tang, Justin D. Shin, Shantanu P. Jadhav. Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits.\u00a0Cell Reports 42, 112246,\u00a0March 28, 2023.\u00a0 Summary &#8220;The ability to abstract information to guide decisions during navigation across changing environments is essential for adaptation and requires the integrity of the hippocampal-prefrontal circuitry. The hippocampus encodes navigational information in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[389,987,346],"tags":[1228,1140,985,1226,1227,148],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2839"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2839"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2839\/revisions"}],"predecessor-version":[{"id":2840,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2839\/revisions\/2840"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2839"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2839"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}