{"id":2850,"date":"2023-04-04T16:18:05","date_gmt":"2023-04-04T06:18:05","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2850"},"modified":"2023-04-04T16:18:05","modified_gmt":"2023-04-04T06:18:05","slug":"how-the-hippocampus-encodes-stores-and-updates-learned-associations","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2850","title":{"rendered":"How the hippocampus encodes, stores and updates learned associations?"},"content":{"rendered":"<p style=\"text-align: justify;\">Jeremy S. Biane, Max A. Ladow, Fabio Stefanini, Sayi P. Boddu, Austin Fan, Shazreh Hassan, Naz Dundar, Daniel L. Apodaca-Montano, Lexi Zichen Zhou, Varya Fayner, Nicholas I. Woods &amp; Mazen A. Kheirbek. <a href=\"https:\/\/www.nature.com\/articles\/s41593-023-01296-6\"><strong>Neural dynamics underlying associative learning in the dorsal and ventral hippocampus<\/strong><\/a>. Nat Neurosci (2023). https:\/\/doi.org\/10.1038\/s41593-023-01296-6<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Animals associate cues with outcomes and update these associations as new information is presented<\/span><\/strong>. This requires the hippocampus, yet <strong><span style=\"color: #ff0000;\">how hippocampal neurons track changes in cue\u2013outcome associations remains unclear<\/span><\/strong>. Using two-photon calcium imaging, <strong><span style=\"color: #ff0000;\">we tracked the same dCA1 and vCA1 neurons across days to determine how responses evolve across phases of odor\u2013outcome learning<\/span><\/strong>. Initially, odors elicited robust responses in dCA1, whereas, in vCA1, odor responses primarily emerged after learning and embedded information about the paired outcome. <strong><span style=\"color: #ff0000;\">Population activity in both regions rapidly reorganized with learning and then stabilized, storing learned odor representations for days, even after extinction or pairing with a different outcome<\/span><\/strong>. Additionally, we found stable, robust signals across CA1 when mice anticipated outcomes under behavioral control but not when mice anticipated an inescapable aversive outcome. <strong><span style=\"color: #ff0000;\">These results show how the hippocampus encodes, stores and updates learned associations and illuminates the unique contributions of dorsal and ventral hippocampus<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Jeremy S. Biane, Max A. Ladow, Fabio Stefanini, Sayi P. Boddu, Austin Fan, Shazreh Hassan, Naz Dundar, Daniel L. Apodaca-Montano, Lexi Zichen Zhou, Varya Fayner, Nicholas I. Woods &amp; Mazen A. Kheirbek. <a href=\"https:\/\/www.nature.com\/articles\/s41593-023-01296-6\"><strong>Neural dynamics underlying associative learning in the dorsal and ventral hippocampus<\/strong><\/a>. Nat Neurosci (2023). https:\/\/doi.org\/10.1038\/s41593-023-01296-6<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jeremy S. Biane, Max A. Ladow, Fabio Stefanini, Sayi P. Boddu, Austin Fan, Shazreh Hassan, Naz Dundar, Daniel L. Apodaca-Montano, Lexi Zichen Zhou, Varya Fayner, Nicholas I. Woods &amp; Mazen A. Kheirbek. Neural dynamics underlying associative learning in the dorsal and ventral hippocampus. Nat Neurosci (2023). https:\/\/doi.org\/10.1038\/s41593-023-01296-6 Abstract &#8220;Animals associate cues with outcomes and update [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[519],"tags":[1233,349,367],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2850"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2850"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2850\/revisions"}],"predecessor-version":[{"id":2851,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2850\/revisions\/2851"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2850"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2850"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2850"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}