{"id":2853,"date":"2023-04-06T11:06:54","date_gmt":"2023-04-06T01:06:54","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2853"},"modified":"2023-04-06T11:06:54","modified_gmt":"2023-04-06T01:06:54","slug":"how-context-recognition-and-heading-retrieval-are-coded-in-ca1-and-how-these-processes-change-with-experience-during-spatial-reorientation%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2853","title":{"rendered":"How  context recognition  and  heading  retrieval  are  coded  in  CA1  and  how  these  processes  change  with experience during spatial reorientation\uff1f"},"content":{"rendered":"<p style=\"text-align: justify;\">Celia M. Gagliardi, Marc E. Normandin, Alexandra T. Keinath, Joshua B. Julian, Matthew R. Lopez, Manuel-Miguel Ramos-Alvarez, Russell A. Epstein, and Isabel A. Muzzio.\u00a0<a href=\"https:\/\/www.researchsquare.com\/article\/rs-2724785\/v1\"><strong><span class=\"rpv-core__text-layer-text\">Distinct neural mechanisms for heading retrieval\u00a0<\/span><span class=\"rpv-core__text-layer-text\">and context recognition in the hippocampus during\u00a0<\/span><\/strong><\/a><span class=\"rpv-core__text-layer-text\"><strong>spatial reorientation<\/strong>.\u00a0https:\/\/doi.org\/10.21203\/rs.3.rs-2724785\/v1<\/span><\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Reorientation, the process of regaining one\u2019s bearings after becoming lost, requires identification of a spatial context (context recognition) and recovery of heading direction within that context (heading retrieval)<\/span><\/strong>. We previously showed that these processes rely on the use of features and geometry, respectively. Here, we examine reorientation behavior in a task that creates contextual ambiguity over a long timescale to demonstrate that mice learn to combine both featural and geometric cues to recover heading with experience. <strong><span style=\"color: #ff0000;\">At the neural level, most CA1 neurons persistently align to geometry, and this alignment predicts heading behavior. However, a small subset of cells shows feature-sensitive place field remapping, which serves to predict context<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">Efficient heading retrieval and context recognition require integration of featural and geometric information in the active network through rate changes<\/span><\/strong>. These data illustrate how context recognition and heading retrieval are coded in CA1 and how these processes change with experience.&#8221;<\/p>\n<p style=\"text-align: justify;\">Celia M. Gagliardi, Marc E. Normandin, Alexandra T. Keinath, Joshua B. Julian, Matthew R. Lopez, Manuel-Miguel Ramos-Alvarez, Russell A. Epstein, and Isabel A. Muzzio.\u00a0<a href=\"https:\/\/doi.org\/10.21203\/rs.3.rs-2724785\/v1\"><strong><span class=\"rpv-core__text-layer-text\">Distinct neural mechanisms for heading retrieval\u00a0<\/span><span class=\"rpv-core__text-layer-text\">and context recognition in the hippocampus during\u00a0<\/span><\/strong><\/a><span class=\"rpv-core__text-layer-text\"><strong>spatial reorientation<\/strong>.\u00a0https:\/\/doi.org\/10.21203\/rs.3.rs-2724785\/v1<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Celia M. Gagliardi, Marc E. Normandin, Alexandra T. Keinath, Joshua B. Julian, Matthew R. Lopez, Manuel-Miguel Ramos-Alvarez, Russell A. Epstein, and Isabel A. Muzzio.\u00a0Distinct neural mechanisms for heading retrieval\u00a0and context recognition in the hippocampus during\u00a0spatial reorientation.\u00a0https:\/\/doi.org\/10.21203\/rs.3.rs-2724785\/v1 Abstract &#8220;Reorientation, the process of regaining one\u2019s bearings after becoming lost, requires identification of a spatial context (context recognition) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[1235,1234,349,1236],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2853"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2853"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2853\/revisions"}],"predecessor-version":[{"id":2854,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2853\/revisions\/2854"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2853"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2853"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}