{"id":2879,"date":"2023-06-07T10:22:31","date_gmt":"2023-06-07T00:22:31","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2879"},"modified":"2023-06-07T10:22:31","modified_gmt":"2023-06-07T00:22:31","slug":"what-are-the-mechanisms-of-memory-storage-and-retrieval-in-hippocampal-area-ca3","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2879","title":{"rendered":"What are the mechanisms of memory storage and retrieval in hippocampal area CA3?"},"content":{"rendered":"<p style=\"text-align: justify;\">Yiding Li, John J. Briguglio, Sandro Romani, Jeffrey C. Magee. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.05.30.542781v1\"><strong>Mechanisms of memory storage and retrieval in hippocampal area CA3<\/strong><\/a>.\u00a0bioRxiv 2023.05.30.542781; doi: https:\/\/doi.org\/10.1101\/2023.05.30.542781<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;Hippocampal area CA3 is thought to play a central role in memory formation and retrieval. <strong><span style=\"color: #ff0000;\">Although various network mechanisms have been hypothesized to mediate these computations, direct evidence is lacking<\/span><\/strong>. Using intracellular membrane potential recordings from CA3 neurons and optogenetic manipulations in behaving mice <strong><span style=\"color: #ff0000;\">we found that place field activity is produced by a symmetric form of Behavioral Timescale Synaptic Plasticity (BTSP) at recurrent synaptic connections among CA3 principal neurons but not at synapses from the dentate gyrus (DG)<\/span><\/strong>. Additional manipulations revealed that <strong><span style=\"color: #ff0000;\">excitatory input from the entorhinal cortex (EC) but not DG was required to update place cell activity based on the animal\u2019s movement<\/span><\/strong>. These data were captured by a computational model that used BTSP and an external updating input to produce attractor dynamics under online learning conditions. Additional theoretical results demonstrate the <strong><span style=\"color: #ff0000;\">enhanced memory storage capacity of such networks, particularly in the face of correlated input patterns<\/span><\/strong>. The evidence sheds light on <strong><span style=\"color: #ff0000;\">the cellular and circuit mechanisms of learning and memory formation in the hippocampus<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">\nOne Sentence Summary<\/p>\n<p style=\"text-align: justify;\">&#8220;Evidence from behaving mice points to cellular and circuit mechanisms that underlie observed attractor dynamics in area CA3.&#8221;<\/p>\n<p style=\"text-align: justify;\">Yiding Li, John J. Briguglio, Sandro Romani, Jeffrey C. Magee. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.05.30.542781v1\"><strong>Mechanisms of memory storage and retrieval in hippocampal area CA3<\/strong><\/a>.\u00a0bioRxiv 2023.05.30.542781; doi: https:\/\/doi.org\/10.1101\/2023.05.30.542781<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yiding Li, John J. Briguglio, Sandro Romani, Jeffrey C. Magee. Mechanisms of memory storage and retrieval in hippocampal area CA3.\u00a0bioRxiv 2023.05.30.542781; doi: https:\/\/doi.org\/10.1101\/2023.05.30.542781 Abstract &#8220;Hippocampal area CA3 is thought to play a central role in memory formation and retrieval. Although various network mechanisms have been hypothesized to mediate these computations, direct evidence is lacking. Using [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,636,346,519],"tags":[1252,148,576,1251],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2879"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2879"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2879\/revisions"}],"predecessor-version":[{"id":2880,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2879\/revisions\/2880"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}