{"id":2926,"date":"2023-12-25T12:57:33","date_gmt":"2023-12-25T02:57:33","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2926"},"modified":"2023-12-25T12:57:33","modified_gmt":"2023-12-25T02:57:33","slug":"how-grid-cells-perform-path-integration-in-multiple-reference-frames-during-self-motion-based-navigation","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2926","title":{"rendered":"How grid cells perform path integration in multiple reference frames during self-motion-based navigation?"},"content":{"rendered":"<p style=\"text-align: justify;\">Jing-Jie Peng, Beate Throm, Maryam Najafian Jazi, Ting-Yun Yen, Hannah Monyer, Kevin Allen. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.12.21.572857v1\"><strong>Grid cells perform path integration in multiple reference frames during self-motion-based navigation<\/strong><\/a>. bioRxiv 2023.12.21.572857; doi: https:\/\/doi.org\/10.1101\/2023.12.21.572857<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;With their periodic firing pattern, <strong><span style=\"color: #ff0000;\">grid cells are considered a fundamental unit of a neural network performing path integration<\/span><\/strong>. The periodic firing patterns of grid cells have been observed mainly during behaviors with little navigational demands, and t<strong><span style=\"color: #ff0000;\">he firing patterns of grid cells in animals navigating 2D environments using path integration are largely unknown<\/span><\/strong>. Here, we recorded<strong><span style=\"color: #ff0000;\"> the activity of grid cells in mice performing the AutoPI task, a task assessing homing based on path integration<\/span><\/strong>. Using artificial deep neural networks to decode the animal&#8217;s moment-to-moment movement vectors, we found that grid cells perform path integration over short trajectories and change their reference frames within single trials. More specifically, grid cell modules re-anchor to a task-relevant object via a translation of the grid pattern. The code for movement direction in grid modules drifts as the animal navigates using self-motion cues, and this drift predicts the homing direction of the mouse. <strong><span style=\"color: #ff0000;\">These results reveal the computations in grid cell circuits during self-motion-based navigation<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Jing-Jie Peng, Beate Throm, Maryam Najafian Jazi, Ting-Yun Yen, Hannah Monyer, Kevin Allen. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.12.21.572857v1\"><strong>Grid cells perform path integration in multiple reference frames during self-motion-based navigation<\/strong><\/a>. bioRxiv 2023.12.21.572857; doi: https:\/\/doi.org\/10.1101\/2023.12.21.572857<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jing-Jie Peng, Beate Throm, Maryam Najafian Jazi, Ting-Yun Yen, Hannah Monyer, Kevin Allen. Grid cells perform path integration in multiple reference frames during self-motion-based navigation. bioRxiv 2023.12.21.572857; doi: https:\/\/doi.org\/10.1101\/2023.12.21.572857 Abstract &#8220;With their periodic firing pattern, grid cells are considered a fundamental unit of a neural network performing path integration. The periodic firing patterns of grid [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346,849],"tags":[1282,103,85,292,511],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2926"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2926"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2926\/revisions"}],"predecessor-version":[{"id":2927,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2926\/revisions\/2927"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}