{"id":2934,"date":"2024-02-01T16:08:33","date_gmt":"2024-02-01T06:08:33","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2934"},"modified":"2024-02-01T16:22:46","modified_gmt":"2024-02-01T06:22:46","slug":"subfield-specific-interneuron-circuits-govern-the-hippocampal-response-to-novelty-in-male-mice","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2934","title":{"rendered":"How subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice"},"content":{"rendered":"<p style=\"text-align: justify;\">Hainmueller, T., Cazala, A., Huang, LW. et al. <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-44882-3\"><strong>Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice<\/strong><\/a>. Nat Commun 15, 714 (2024). https:\/\/doi.org\/10.1038\/s41467-024-44882-3<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;The hippocampus is the brain\u2019s center for episodic memories. Its subregions, the dentate gyrus and CA1-3, are differentially involved in memory encoding and recall. <span style=\"color: #ff0000;\"><strong>Hippocampal principal cells represent episodic features like movement, space, and context, but less is known about GABAergic interneurons<\/strong><\/span>. Here, we performed two-photon calcium imaging of parvalbumin- and somatostatin-expressing interneurons in the dentate gyrus and CA1-3 of male mice exploring virtual environments. Parvalbumin-interneurons increased activity with running-speed and reduced it in novel environments. Somatostatin-interneurons in CA1-3 behaved similar to parvalbumin-expressing cells, but their dentate gyrus counterparts increased activity during rest and in novel environments. Congruently, chemogenetic silencing of dentate parvalbumin-interneurons had prominent effects in familiar contexts, while silencing somatostatin-expressing cells increased similarity of granule cell representations between novel and familiar environments. <span style=\"color: #ff0000;\"><strong>Our data indicate unique roles for parvalbumin- and somatostatin-positive interneurons in the dentate gyrus that are distinct from those in CA1-3 and may support routing of novel information<\/strong><\/span>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Hainmueller, T., Cazala, A., Huang, LW. et al. <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-44882-3\"><strong>Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice<\/strong><\/a>. Nat Commun 15, 714 (2024). https:\/\/doi.org\/10.1038\/s41467-024-44882-3<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hainmueller, T., Cazala, A., Huang, LW. et al. Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice. Nat Commun 15, 714 (2024). https:\/\/doi.org\/10.1038\/s41467-024-44882-3 Abstract &#8220;The hippocampus is the brain\u2019s center for episodic memories. Its subregions, the dentate gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal principal cells represent [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[1285],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2934"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2934"}],"version-history":[{"count":2,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2934\/revisions"}],"predecessor-version":[{"id":2936,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2934\/revisions\/2936"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2934"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2934"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2934"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}