{"id":2949,"date":"2024-02-22T16:38:17","date_gmt":"2024-02-22T06:38:17","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2949"},"modified":"2024-02-22T16:38:17","modified_gmt":"2024-02-22T06:38:17","slug":"how-egocentric-coding-properties-arise-from-its-presynaptic-inputs-and-how-egocentric-cells-represent-items-across-different-behavioral-contexts","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2949","title":{"rendered":"How egocentric coding properties arise from its presynaptic inputs, and how egocentric cells represent items across different behavioral contexts?"},"content":{"rendered":"<p style=\"text-align: justify;\">Cheng, Ning, Qiqi Dong, Zhen Zhang, Li Wang, Xiaojing Chen, and Cheng Wang. &#8220;<a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273%2823%2900892-9\"><strong>Egocentric processing of items in spines, dendrites, and somas in the retrosplenial cortex<\/strong><\/a>.&#8221; Neuron (2023).<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n&#8220;Egocentric representations of external items are essential for spatial navigation and memory. Here, <strong><span style=\"color: #ff0000;\">we explored the neural mechanisms underlying egocentric processing in the retrosplenial cortex (RSC), a pivotal area for memory and navigation<\/span><\/strong>. Using one-photon and two-photon calcium imaging, <strong><span style=\"color: #ff0000;\">we identified egocentric tuning for environment boundaries in dendrites, spines, and somas of RSC neurons<\/span><\/strong> (egocentric boundary cells) in the open-field task. Dendrites with egocentric tuning tended to have similarly tuned spines. <strong><span style=\"color: #ff0000;\">We further identified egocentric neurons representing landmarks in a virtual navigation task or remembered cue location in a goal-oriented task, respectively<\/span><\/strong>. These neurons formed an independent population with <strong><span style=\"color: #ff0000;\">egocentric boundary cells<\/span><\/strong>, suggesting that dedicated neurons with microscopic clustering of functional inputs shaped egocentric boundary processing in RSC and that RSC adopted a labeled line code with distinct classes of egocentric neurons responsible for representing different items in specific behavioral contexts, which could lead to efficient and flexible computation.&#8221;<\/p>\n<p style=\"text-align: justify;\">Cheng, Ning, Qiqi Dong, Zhen Zhang, Li Wang, Xiaojing Chen, and Cheng Wang. &#8220;<a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273%2823%2900892-9\"><strong>Egocentric processing of items in spines, dendrites, and somas in the retrosplenial cortex<\/strong><\/a>.&#8221; Neuron (2023).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cheng, Ning, Qiqi Dong, Zhen Zhang, Li Wang, Xiaojing Chen, and Cheng Wang. &#8220;Egocentric processing of items in spines, dendrites, and somas in the retrosplenial cortex.&#8221; Neuron (2023). Summary &#8220;Egocentric representations of external items are essential for spatial navigation and memory. Here, we explored the neural mechanisms underlying egocentric processing in the retrosplenial cortex (RSC), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[346,532],"tags":[1301,589,507,1302,1300],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2949"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2949"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2949\/revisions"}],"predecessor-version":[{"id":2950,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2949\/revisions\/2950"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}