{"id":2988,"date":"2024-07-14T09:48:34","date_gmt":"2024-07-13T23:48:34","guid":{"rendered":"https:\/\/www.cognav.net\/?p=2988"},"modified":"2024-07-14T09:48:34","modified_gmt":"2024-07-13T23:48:34","slug":"how-retrosplenial-inputs-drive-visual-representations-in-the-medial-entorhinal-cortex","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=2988","title":{"rendered":"How retrosplenial inputs drive visual representations in the medial entorhinal cortex?"},"content":{"rendered":"<p style=\"text-align: justify;\">Dubanet, Olivier, and Michael J. Higley. &#8220;<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)00799-X\"><strong>Retrosplenial inputs drive visual representations in the medial entorhinal cortex<\/strong><\/a>.&#8221; Cell Reports 43.7 (2024).<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n&#8220;The importance of visual cues for navigation and goal-directed behavior is well established, although <span style=\"color: #ff0000;\"><strong>the neural mechanisms supporting sensory representations in navigational circuits are largely unknown<\/strong><\/span>. Navigation is fundamentally dependent on the medial entorhinal cortex (MEC), which receives direct projections from neocortical visual areas, including the retrosplenial cortex (RSC). Here, we perform high-density recordings of MEC neurons in awake, head-fixed mice presented with simple visual stimuli and assess the dynamics of sensory-evoked activity. <strong><span style=\"color: #ff0000;\">We find that a large fraction of neurons exhibit robust responses to visual input<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">Visually responsive cells are located primarily in layer 3 of the dorsal MEC<\/span><\/strong> and can be separated into subgroups based on functional and molecular properties. Furthermore, optogenetic suppression of RSC afferents within the MEC strongly reduces visual responses. Overall, <strong><span style=\"color: #ff0000;\">our results demonstrate that the MEC can encode simple visual cues in the environment that may contribute to neural representations of location necessary for accurate navigation<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Dubanet, Olivier, and Michael J. Higley. &#8220;<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)00799-X\"><strong>Retrosplenial inputs drive visual representations in the medial entorhinal cortex<\/strong><\/a>.&#8221; Cell Reports 43.7 (2024).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dubanet, Olivier, and Michael J. Higley. &#8220;Retrosplenial inputs drive visual representations in the medial entorhinal cortex.&#8221; Cell Reports 43.7 (2024). Summary &#8220;The importance of visual cues for navigation and goal-directed behavior is well established, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the medial entorhinal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346,419],"tags":[1321,1319,1012,1320,1318],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2988"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2988"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2988\/revisions"}],"predecessor-version":[{"id":2989,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/2988\/revisions\/2989"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2988"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2988"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2988"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}